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SML1821

Sigma-Aldrich

Imidafenacin hydrochloride

≥95% (HPLC)

Synonym(s):

2-Methyl-α,α-diphenyl-1H-imidazole-1-butanamide hydrochloride, 4-(2-Methyl-1-imidazolyl)-2,2-diphenylbutanamide hydrochloride, 4-(2-Methyl-1H-imidazol-1-yl)-2,2-diphenylbutanamide hydrochloride, CID 6433090 hydrochloride, HY-B06626433090 hydrochloride, KRP-197 hydrochloride, ONO-8025 hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C20H21N3O · HCl
CAS Number:
893421-54-0
Molecular Weight:
355.86
MDL number:
MFCD09833703
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

H2O: 15 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

Imidafenacin exhibits anticholinergic properties. It also has potential therapeutic effects on prostatic hyperplasia.
Imidafenacin is a potent antimuscarinic agent that exhibits selectivity toward muscarinic M3 receptors with Kb of 0.317 nM. Imidafenacin is used for treating overactive bladder.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Takanobu Yamazaki et al.
European journal of pharmacology, 791, 72-77 (2016-10-30)
Imidafenacin, an antimuscarinic agent for treating overactive bladder, has an antidiuretic effect, but the detailed mechanisms of action remain unclear. The cholinergic and vasopressin systems are known to interact, for example, in the suppression of vasopressin-induced water reabsorption through muscarinic
Kuanglei Wang et al.
Bioorganic chemistry, 98, 103757-103757 (2020-03-29)
Carbamyl is considered a privileged structure in medicinal chemistry. It has a wide range of biological activities such as antimicrobial, anticancer, anti-epilepsy, for which the best evidence is a number of marketed carbamyl-containing drugs. Carbamyl is formed of primary amine
Naoki Aizawa et al.
The Journal of urology, 193(4), 1423-1432 (2014-09-16)
Imidafenacin and fesoterodine are used to treat overactive bladder. Imidafenacin, fesoterodine and its active metabolite 5-hydroxymethyl tolterodine are muscarinic receptor antagonists. It is believed that these agents act on afferent nerves in addition to smooth muscle. We investigated the effects
Masayuki Takeda et al.
Urology, 82(4), 887-893 (2013-08-21)
To evaluate the effects of add-on treatment with an anticholinergic (imidafenacin) on persistent overactive bladder (OAB) symptoms despite α-blocker (tamsulosin) treatment in patients with benign prostatic hyperplasia (BPH). Patients with BPH ≥50 years old, with urinary urgency at least once per
Shiori Kuraoka et al.
Journal of pharmacological sciences, 131(3), 184-189 (2016-07-20)
The present study aimed to directly characterize specific binding sites of tritium ([(3)H])-labeled imidafenacin, a new radioligand for labeling muscarinic receptors, in the bladder and other peripheral or central nervous tissues of rats. Muscarinic receptors in rat tissues were measured

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