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Key Documents

SAB2501472

Sigma-Aldrich

Anti-SLC2A4 (C-terminal) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-GLUT4, Glucose transporter 4, Insulin-responsive glucose transporter type 4, Solute carrier family 2 (facilitated glucose transporter), member 4

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, mouse, human, bovine

technique(s)

ELISA: suitable
immunohistochemistry: suitable
western blot: suitable

UniProt accession no.

P14672

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SLC2A4(6517)

General description

Solute carrier family 2 member 4 (SLC2A4) is also known as glucose transporter-4 (GLUT4). It is highly expressed in adipose tissue and skeletal muscles. The gene encoding SLC2A4 is localized on human chromosome 17p13.

Immunogen

Peptide with sequence TELEYLGPDEND, from the C-terminal region of the protein sequence according to NP_001033.1

Biochem/physiol Actions

Solute carrier family 2 member 4 (SLC2A4) transports glucose into cells in response to insulin. Levels of this protein have been shown to be reduced in type 2 diabetes.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Malgorzata Malodobra-Mazur et al.
Gene, 576(1 Pt 3), 499-504 (2015-11-04)
The glucose uptake by numerous cells like adipocytes or skeletal muscle cells requires activation of specific proteins called glucose transporters. GLUT4 content and its activation as well as SLC2A4 gene expression level are decreased in patients with type 2 diabetes.
Wei-Feng Shan et al.
Journal of Zhejiang University. Science. B, 12(8), 677-682 (2011-07-29)
Decreased glucose tolerance and diabetes are frequently observed in advanced liver cirrhosis patients and may be related to insulin resistance. Glucose transporter-4 (GLUT4), one of the most important glucose transporters, plays a key role in the development of type 2
G I Bell et al.
Diabetes, 38(8), 1072-1075 (1989-08-01)
Glucose uptake by heart, skeletal muscle, and adipose tissue is acutely regulated by insulin, which stimulates facilitative glucose transport, at least in part, by promoting the translocation of transporters from an intracellular pool to the plasma membrane. cDNAs encoding the

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