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RAB0017

Sigma-Aldrich

Human ANGPTL4 ELISA Kit

for serum, plasma and cell culture supernatants

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About This Item

UNSPSC Code:
41116158
NACRES:
NA.32

species reactivity

human

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable
capture ELISA: suitable

input

sample type cell culture supernatant(s)
sample type serum
sample type plasma

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 20 pg/mL
standard curve range: 27.4-20000 pg/mL

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... ANGPTL4(51378)

General description

The Human ANGPTL4 (Angiopoietin-like 4) ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human ANGPTL4 in serum, plasma and cell culture supernatants.

Immunogen

Recombinant Human Angiopoietin-like 4

Application

For research use only. Not for use in diagnostic procedures.
Human angiopoietin-like protein 4 (ANGPTL4) ELISA kit has been used for the quantitative measurement of ANGPTL4 in serum and urinary samples.

Biochem/physiol Actions

Angiopoietin like 4 (ANGPTL4) possesses a characteristic large fibrinogen/angiopoietin like domain. It inhibits lipoprotein lipase and thus increases plasma triglyceride levels. The protein regulates the uptake of free fatty acids in fasting and fed conditions. ANGPTL4 is also involved in homeostasis, insulin sensitivity and apoptosis of vascular endothelial cells. It has been reported to have a role in atherosclerosis and may modulate inflammatory responses.

Other Notes

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

Kit Components Also Available Separately

Product No.
Description
SDS
  • RABELADAELISA 1X Assay/Sample Diluent Buffer A (Item D1)SDS
  • RABELADBELISA 5X Assay/Sample Diluent Buffer B (Item E1)SDS
  • RABSTOP3ELISA Stop Solution (Item I)SDS
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)SDS
  • RABWASH420X Wash Buffer (Item B)SDS

Pictograms

Corrosion
GHS05

Signal Word

Warning

Hazard Statements

H290

Precautionary Statements

P234 - P390

Hazard Classifications

Met. Corr. 1

Storage Class Code

8A - Combustible corrosive hazardous materials

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Gabriel Cara-Fuentes et al.
PloS one, 12(4), e0176198-e0176198 (2017-04-26)
Minimal Change Disease (MCD) is the most common type of nephrotic syndrome in children. Angiopoietin-like-4 (Angplt4) has been proposed as mediator of proteinuria in MCD. The aim of this study was to evaluate the role of Angptl4 as a biomarker
Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease
Frederick E
The New England Journal of Medicine (2016)
Xuekai Wang et al.
European journal of pharmacology, 858, 172342-172342 (2019-05-28)
Danshen (Salvia miltiorrhiza) and prednisone are extensively applied in the treatment of kidney disease. Salvianolic acid A (SAA), the major biologically active component of Danshen, which has various biological effects. Our previous findings have demonstrated the renoprotective effect of SAA
Xun Chi et al.
The Journal of biological chemistry, 290(19), 11865-11877 (2015-03-27)
The release of fatty acids from plasma triglycerides for tissue uptake is critically dependent on the enzyme lipoprotein lipase (LPL). Hydrolysis of plasma triglycerides by LPL can be disrupted by the protein angiopoietin-like 4 (ANGPTL4), and ANGPTL4 has been shown
Angiopoietin-like-4 and minimal change disease
Gabriel C
PLoS ONE (2017)
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