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PZ0124

Sigma-Aldrich

CP-66713

≥98% (HPLC)

Synonym(s):

8-chloro-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxalin-4-amine, PF-1716311

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About This Item

Empirical Formula (Hill Notation):
C15H10ClN5
CAS Number:
91896-57-0
Molecular Weight:
295.73
MDL number:
MFCD17215961
UNSPSC Code:
51111800
PubChem Substance ID:
329823714
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: ≥5 mg/mL

storage temp.

2-8°C

SMILES string

Nc1nc2ccc(Cl)cc2n3c(nnc13)-c4ccccc4

InChI

1S/C15H10ClN5/c16-10-6-7-11-12(8-10)21-14(9-4-2-1-3-5-9)19-20-15(21)13(17)18-11/h1-8H,(H2,17,18)

InChI key

PBENJWAFQLORQL-UHFFFAOYSA-N

Biochem/physiol Actions

CP-66713 is an adenosine A2 receptor antagonist.

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Y Sekino et al.
Biochemical and biophysical research communications, 181(3), 1010-1014 (1991-12-31)
The effects of adenosine A2 receptor antagonist (CP-66713) on long-term potentiation were studied using guinea pig hippocampal slices in a perfusion system. Tetanic stimulation of Schaffer collateral input which was applied during perfusion of CP-66713 (10 microM), did not induce
K A Kirkpatrick et al.
British journal of pharmacology, 110(3), 949-954 (1993-11-01)
1. The effects of A1 and A2a adenosine receptor agonists on the veratridine-evoked release of [3H]-acetylcholine ([3H]-ACh) from rat striatal synaptosomes was investigated by use of the A1-selective agonist, R-PIA and the 185 fold selective A2a agonist, CGS 21680. The
S V Vellucci et al.
Psychopharmacology, 111(3), 383-388 (1993-01-01)
The ipsilateral intrastriatal administration of the specific adenosine A2a receptor agonist, 2-[p-(2-carboxyethyl)phenethylamino]-5'-N-ethylcarboxamido adenosine (CGS 21680), produced a dose related decrease in apomorphine-induced rotation in the unilaterally 6-hydroxydopamine-lesioned rat. This effect could be reversed by intrastriatal infusions of the A2a antagonist
E M O'Kane et al.
European journal of pharmacology, 362(1), 17-25 (1998-12-29)
Previous work has been carried out on the effects of adenosine on transmitter release and on the excitability of postsynaptic neurones, but little is known about the effects of adenosine on the coupling between the two. In this study, we
T Matsugi et al.
Investigative ophthalmology & visual science, 38(13), 2695-2701 (1998-01-07)
To investigate the effect of adenosine on the contractile tone of cultured bovine retinal pericytes. Changes in the contractile tone were quantified as the changes in the summed length of wrinkles induced by pericytes on the silicone surface on which
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