378R-1

Cadherin-17 (SP183) Rabbit Monoclonal Antibody

• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100; 500
• conjugate: unconjugated
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: SP183, monoclonal
• description: For In Vitro Diagnostic Use in Select Regions (See Chart)
• form: buffered aqueous solution
• species reactivity: human
• packaging: vial of 0.1 mL concentrate (378R-14); vial of 0.5 mL concentrate (378R-15); bottle of 1.0 mL predilute (378R-17); vial of 1.0 mL concentrate (378R-16); bottle of 7.0 mL predilute (378R-18)
• manufacturer/tradename: Cell Marque^™
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
• isotype: IgG
• control: colorectal carcinoma
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: cytoplasmic, membranous
• Gene Information: human ... CDH17(1015)

Description

General description

Cadherin-17, also called liver-intestinal (LI) cadherin or human peptide transporter-1, is a member of the cadherin superfamily. Unlike some classic cadherins, such as E-, N-, and P-cadherins, cadherin-17 has seven cadherin repeats instead of five within the extracellular domain and only 20 amino-acid residues in the cytoplasmic domain. The markedly short cytoplasmic domain lacks homology with other cadherins and the adhesive function of cadherin-17 is not dependent on association with other cytoplasmic proteins. The subcellular distribution of cadherin-17 is also different from classic cadherins. In intestinal epithelial cells, E-cadherin is concentrated in adherens junctions whereas cadherin-17 is evenly distributed along the lateral contact area. Human normal tissues that are strongly stained with cadherin-17 include appendicular epithelium, colonic epithelium, and small intestinal epithelium. Other normal human tissues are not stained with cadherin-17. The results above indicate cadherin-17 can be used as a marker for identification of primary sites of tumors. In-house studies have shown that cadherin-17 expression is usually diffuse and strong in colorectal adenocarcinomas, whereas it is usually focal or scattered in adenocarcinomas of the stomach, pancreas and bile duct, and is virtually absent in tumors of other anatomic sites.

Quality

IVD

IVD

IVD

RUO

Linkage

Cadherin-17 Positive Control Slides, Product No. 378S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany