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32492

Supelco

Florfenicol amine

VETRANAL®, analytical standard

Synonym(s):

R)-α-[(1S)-1-Amino-2-fluoroethyl]-4-(methylsulfonyl)benzenemethanol, D-(−)-threo-2-Amino-3-fluoro-1-[4-(methylsulfonyl)phenyl]-1-propanol

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About This Item

Empirical Formula (Hill Notation):
C10H14FNO3S
CAS Number:
Molecular Weight:
247.29
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

CS(=O)(=O)c1ccc(cc1)[C@@H](O)[C@H](N)CF

InChI

1S/C10H14FNO3S/c1-16(14,15)8-4-2-7(3-5-8)10(13)9(12)6-11/h2-5,9-10,13H,6,12H2,1H3/t9-,10-/m1/s1

InChI key

XLSYLQDVLAXIKK-NXEZZACHSA-N

General description

Florfenicol amine is a polar metabolite of florfenicol.

Application

Florfenicol amine may be used as an analytical reference standard for the determination of the analyte in:
  • Poultry and porcine muscle and liver by gas chromatography-negative chemical ionization mass spectrometry (GC-NCI/MS) with selected ion monitoring (SIM) detection.
  • Food samples by ultra-high performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UHPLC-ESI-MS/MS) operating in selected reaction monitoring (SRM) detection mode.
  • Chicken muscle by LC-ESI-MS/MS with multiple reaction monitoring (MRM) detection.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


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Kaizhou Xie et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(23), 2351-2354 (2011-07-12)
A specific, sensitive and widely applicable reversed-phase high-performance liquid chromatography with fluorescence detection (RP-HPLC-FLD) method was developed for the simultaneous determination of thiamphenicol (TAP), florfenicol (FF) and florfenicol amine (FFA) in eggs. Samples were extracted with ethyl acetate-acetonitrile-ammonium hydroxide (49:49:2
A P Pfenning et al.
Journal of AOAC International, 83(1), 26-30 (2000-02-29)
A gas chromatographic (GC) method is presented for determining residues of chloramphenicol (CAP), florfenicol (FF), florfenicol amine (FFa), and thiamphenicol (TAP) in shrimp tissues, with meta-nitrochloramphenicol (mCAP) as the internal standard. The composited shrimp is extracted with basic ethyl acetate
B-K Park et al.
Journal of veterinary pharmacology and therapeutics, 29(1), 37-40 (2006-01-20)
The pharmacokinetics of florfenicol and its metabolite, florfenicol amine, was investigated after its intravenous (i.v.) and oral (p.o.) administration of 20 mg/kg of body weight in Korean catfish (Silurus asotus). After i.v. florfenicol injection (as a bolus), the terminal half-life
Suxia Zhang et al.
Journal of AOAC International, 89(5), 1437-1441 (2006-10-18)
A rapid and sensitive gas chromatography method was developed for the simultaneous determination of florfenicol (FF) and its metabolite florfenicol amine (FFA) in fish, shrimp, and swine muscle. The extracted samples were defatted with hexane and cleaned up by solid-phase
Suxia Zhang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 875(2), 399-404 (2008-10-18)
A reliable and sensitive liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) confirmation method has been developed for the simultaneous determination of chloramphenicol (CAP), thiamphenicol (TAP), florfenicol (FF), and florfenicol amine (FFA) in chicken muscle. Samples were extracted with basic ethyl acetate

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