361552

GSK-3 Inhibitor IX

InSolution, ≥97%

• Synonym(s): InSolution GSK-3 Inhibitor IX
• Empirical Formula (Hill Notation): C₁₆H₁₀BrN₃O₂
• CAS Number: 667463-62-9
• Molecular Weight: 356.17
• MDL number: MFCD08705318
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥97% (HPLC)
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• shipped in: wet ice
• storage temp.: 2-8°C
• SMILES string: Brc1cc2c(cc1)\C(=C3\Nc4c(cccc4)C\3N=O)\C(=O)N2
• InChI: 1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,14,18H,(H,19,21)/b15-13-
• InChI key: WFRDXNRAUPBBTO-SQFISAMPSA-N

Description

General description

A cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC₅₀ = 5 nM). Specificity was confirmed using various Cdk′s (IC₅₀ = 83 nM for Cdk5/p25, 300 nM for Cdk2/cyclin A, 320 nM for Cdk1/cyclin B, and 10 µM for Cdk4/cyclin D1), MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK (IC₅₀ ≥ 10 µM). Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency of human and murine embryonic stem cells (ESCs).

Biochem/physiol Actions

Cell permeable: yes

Product competes with ATP.

Reversible: no

Target IC₅₀: 5 nM against GSK-3α/β

Packaging

Packaged under inert gas

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Physical form

A 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361550) in DMSO.

Other Notes

Polychronopoulos, P., et al. 2004. J. Med. Chem.47, 935.
Sato, N., et al. 2004. Nat. Med.10, 55.
Meijer, L., et al. 2003. Chem. Biol.10, 1255.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): 188.6 °F
• Flash Point(C): 87 °C