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P30004

Sigma-Aldrich

1-Phenylpiperazine

≥97.0%

Synonym(s):

N-Phenyldiethylenediamine

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About This Item

Empirical Formula (Hill Notation):
C10H14N2
CAS Number:
92-54-6
Molecular Weight:
162.23
Beilstein:
132157
EC Number:
202-165-6
MDL number:
MFCD00005957
UNSPSC Code:
12352100
PubChem Substance ID:
24898377
NACRES:
NA.22

Assay

≥97.0%

refractive index

n20/D 1.588 (lit.)

bp

286 °C (lit.)

density

1.062 g/mL at 25 °C (lit.)

SMILES string

C1CN(CCN1)c2ccccc2

InChI

1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2

InChI key

YZTJYBJCZXZGCT-UHFFFAOYSA-N

Gene Information

mouse ... Htr3a(15561)
rat ... Drd2(24318) , Htr1a(24473)

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Pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

Signal Word

Danger

Hazard Statements

H301,H310,H314

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 3 Oral - Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

284.0 °F

Flash Point(C)

140 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Gilda Neves et al.
Pharmacology, biochemistry, and behavior, 89(1), 23-30 (2007-12-18)
Previous studies have demonstrated that LASSBio-579 and LASSBio-581, two N-phenylpiperazine derivatives designed for the treatment of schizophrenia, are presynaptic dopamine D(2) receptor agonists that induce a hypothermic effect in mice that is not mediated by dopamine receptor activation. The aim
Romano Di Fabio et al.
Journal of medicinal chemistry, 52(10), 3238-3247 (2009-04-25)
In an effort to discover novel druglike NK(1) receptor antagonists a new series of suitably substituted C-phenylpiperazine derivatives was identified by an appropriate chemical exploration of related N-phenylpiperazine analogues, with the specific aim to maximize their in vitro affinity and
Jadwiga Handzlik et al.
Bioorganic & medicinal chemistry, 20(7), 2290-2303 (2012-03-03)
An association between α(1)-adrenoceptor affinities, hERG K(+)-antagonistic properties and antiarrhythmic activities for a series of phenylpiperazine derivatives of hydantoin (2a-21a) was investigated. New compounds were synthesized and tested for their affinity for α(1)-adrenoceptors in radioligand binding assay using [(3)H]-prazosin as
Daniela Huber et al.
Bioorganic & medicinal chemistry, 20(1), 455-466 (2011-11-22)
Merging two arylamidoalkyl substituted phenylpiperazines as prototypical recognition elements for dopamine D(2)-like receptors by oligoethylene glycol linkers led to a series of bivalent ligands. These dimers were investigated in comparison to their monomeric analogues for their dopamine D(2long), D(2short), D(3)
Rodolfo do Couto Maia et al.
Expert opinion on therapeutic patents, 22(10), 1169-1178 (2012-09-11)
The N-phenylpiperazine subunit represents one of the most versatile scaffolds used in the medicinal chemistry field. Recently, some N-phenylpiperazine derivatives have reached late stage clinical trials for the treatment of CNS disorders, thus, this is clearly a molecular template that
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