911399
Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)
PEG average Mn 2,000, PLGA average Mn 10,000, lactide:glycolide 80:20
Synonym(s):
PEG-PLGA, PEG2K-PLGA10K, mPEG-b-PLGA
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About This Item
Linear Formula:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
UNSPSC Code:
12352112
NACRES:
NA.23
Quality Level
form
powder or chunks
feed ratio
lactide:glycolide 80:20
mol wt
PEG average Mn 2,000 (by NMR)
PLGA average Mn 10,000 (by NMR)
color
off-white to faint brown
storage temp.
−20°C
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Application
This polymer is a amphiphilic diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PLGA block. This biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). Additionally, well-defined nanoparticles with tunable size and properties can be prepared by altering the molecular weight ratios between hydrophilic and hydrophobic blocks, as well as by controlling formulation parameters.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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