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119660

Sigma-Aldrich

Tris(2-chloroethyl) phosphate

97%

Synonym(s):

Phosphoric acid tris(2-chloroethyl) ester

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About This Item

Linear Formula:
(ClCH2CH2O)3P(O)
CAS Number:
115-96-8
Molecular Weight:
285.49
EC Number:
204-118-5
MDL number:
MFCD00000967
UNSPSC Code:
12352100
PubChem Substance ID:
24847295
NACRES:
NA.22

vapor pressure

<10 mmHg ( 25 °C)

Assay

97%

refractive index

n20/D 1.472 (lit.)

bp

192 °C/10 mmHg (lit.)

solubility

H2O: soluble 7.82 g/L

density

1.39 g/mL at 25 °C (lit.)

SMILES string

ClCCOP(=O)(OCCCl)OCCCl

InChI

1S/C6H12Cl3O4P/c7-1-4-11-14(10,12-5-2-8)13-6-3-9/h1-6H2

InChI key

HQUQLFOMPYWACS-UHFFFAOYSA-N

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General description

Tris(2-chloroethyl) phosphate is used as a flame retardant in plastics, especially inflexible foams used in automobiles and furniture and in rigid foams used for building insulation.

Application

Tris(2-chloroethyl) phosphate was used in dynamic air sampling of airborne organophosphate triesters using a solid-phase microextraction device.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H302,H351,H360

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

449.6 °F - closed cup

Flash Point(C)

232 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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D E Chapman et al.
Fundamental and applied toxicology : official journal of the Society of Toxicology, 17(2), 215-224 (1991-08-01)
Previous studies indicate that tris(2-chloroethyl)phosphate (TCP) preferentially produces hippocampal brain lesions in female versus male rats, and the expression of these lesions is inversely related to the in vivo rate of TCP metabolism. In the present studies, TCP (0.17 mM
Xianghao Ren et al.
Journal of water and health, 10(4), 522-530 (2012-11-21)
Being a typical micropollutant, tris-(2-chloroethyl)-phosphate (TCEP) is often found in aquatic environments. However, the potential effects of TCEP at environmental concentrations on apoptotic mechanisms are mostly unknown. Thus, the purpose of this study is to investigate the apoptotic regulatory protein
M Sala et al.
European journal of cancer & clinical oncology, 18(12), 1337-1344 (1982-12-01)
Tris(2,3-dibromopropyl)phosphate (Tris-BP) and Tris(2-chloroethyl) orthophosphate (Genomoll P) were analyzed for mutagenic and carcinogenic activity in several in vitro and in vivo mammalian systems. In the in vitro tests both Tris-BP and Genomoll P increased sister chromatid exchanges in V79 cells
K Dix et al.
Journal of pharmaceutical sciences, 83(11), 1622-1629 (1994-11-01)
The pharmacokinetics of tris(2-chloroethyl) phosphate (TRCP, 20 mg/kg, iv) were investigated in awake male and female and anesthetized male Fischer 344 (F344) rats by conventional (CONV) sampling/detection methods (blood withdrawal with sample workup and analysis for TRCP). TRCP pharmacokinetics were
G Ingerowski et al.
Indoor air, 11(3), 145-149 (2001-08-28)
The chlorinated organo-phosphate triesters, tris(2-chloroethyl)-phosphate (TCEP) and tris(monochloroisopropyl)-phosphate (TCPP), are employed in consumer articles for indoor usage, e.g. flame retardants and plasticizers in foam material as well as in paints, varnishes and wallpapers. As a result of this widespread usage
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