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Isopropyl β-D-1-thiogalactopyranoside

Name: Isopropyl β-<SC>D</SC>-1-thiogalactopyranoside
Brand: SIGMA

Synonym(s):

IPTG, Isopropyl β-D-thiogalactoside

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About This Item

Empirical Formula (Hill Notation):

C₉H₁₈O₅S

CAS Number:

367-93-1

Molecular Weight:

238.30

EC Number:

206-703-0

UNSPSC Code:

12352201

MDL number:

MFCD00063273

Beilstein/REAXYS Number:

4631

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Properties

biological source

synthetic

Quality Segment

300

application(s)

downstream processes
pharma/biopharma processes

storage temp.

2-8°C

SMILES string

CC(C)S[C@@H]1OC(CO)[C@H](O)C(O)[C@H]1O

InChI

1S/C9H18O5S/c1-4(2)15-9-8(13)7(12)6(11)5(3-10)14-9/h4-13H,3H2,1-2H3/t5-,6+,7+,8-,9+/m1/s1

InChI key

BPHPUYQFMNQIOC-NXRLNHOXSA-N

Description

General description

Our SAFC^® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.

Application

IPTG is commonly used in cloning procedures that require induction of β-galactosidase activity. It is used in conjunction with X-Gal or Bluo-Gal in blue-white selection of recombinant bacterial colonies that induce expression of the lac operon in Escherichia coli. IPTG functions by binding to the lacI repressor and altering its conformation, which prevents the repression of the β-galactosidase coding gene lacZ.

Other Notes

Non-metabolizable galactose analog.

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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This Item	I5502	I1284	420291
SAFC PHG0010 Isopropyl β-D-1-thiogalactopyranoside	Sigma-Aldrich I5502 Isopropyl β-D-1-thiogalactopyranoside	Sigma-Aldrich I1284 Isopropyl β-D-thiogalactopyranoside solution	Millipore 420291 IPTG, Animal-Free, High Purity
description -	description ≥99% (TLC)	description ReadyMade IPTG solution for Blue-white screening	description Inducer of β-D-galactosidase. Used in the stimulation of β-galactosidase in cellular systems in which dioxane would disrupt normal cell function. Contains no animal-derived products.
biological source synthetic	biological source -	biological source -	biological source -
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C
Quality Level 300	Quality Level 300, 200	Quality Level 200	Quality Level 100

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Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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