L2777
Lisinopril
ACE Inhibitor
Synonym(s):
(S)-Nα-(1-Carboxy-3-phenylpropyl)-Lys-Pro
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Recommended Products
![N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly](/deepweb/assets/sigmaaldrich/product/structures/225/349/530bc714-b1a8-4fdb-8082-a39329ee730a/640/530bc714-b1a8-4fdb-8082-a39329ee730a.png)
Quality Level
General description
Lisinopril is a nonsulfhydryl angiotensin-converting enzyme (ACE) inhibitor. It is used in the treatment of heart failure and hypertension. Lisinopril is an antihypertensive and anticongestive agent, like other members of its family. It is water-soluble and possesses weak chelating properties.
Application
Lisinopril has been used as an angiotensin-converting enzyme (ACE) inhibitor:
- in combination with spironolactone, to study their effects on cardiac and skeletal muscles in the Duchenne muscular dystrophy (DMD) mice model
- standard in in vitro ACE inhibitory assay
- as a negative control in ACE enzymatic assay
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Repr. 1A - STOT RE 2
Target Organs
Kidney
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
M L Ricketts et al.
Clinical science (London, England : 1979), 96(6), 669-675 (1999-05-21)
In the kidney and colon 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) inactivates cortisol to cortisone, thereby protecting the non-selective mineralocorticoid receptor from cortisol. Deficiency of 11beta-HSD2 results in cortisol-mediated sodium retention and hypertension, suggesting that the physiological regulation of 11beta-HSD2 in
A A Patchett et al.
Nature, 288(5788), 280-283 (1980-11-20)
Much current attention focuses on the renin-angiotensin system in relation to mechanisms controlling blood pressure and renal function. Recent demonstrations (ref. 1, ref. 2 and refs therein) that angiotensin-converting enzyme inhibitors show promising clinical antihypertensive properties have been of particular
Comparative Effects of Low and High Doses of the
Angiotensin-Converting Enzyme Inhibitor, Lisinopril, on
Morbidity and Mortality in Chronic Heart Failure
Angiotensin-Converting Enzyme Inhibitor, Lisinopril, on
Morbidity and Mortality in Chronic Heart Failure
Milton Packer
Clinical and Investigative Medicine. Medecine Clinique Et Experimentale (2017)
E J Wallis et al.
Clinical pharmacology and therapeutics, 64(4), 439-449 (1998-11-03)
The antihypertensive response to angiotensin-converting enzyme (ACE) inhibitors may be attenuated by a compensatory decrease in atrial natriuretic factor production. If so, inhibition of atrial natriuretic factor breakdown by neutral endopeptidase (NEP) may enhance the antihypertensive effects of ACE inhibition.
Antihypertensive Drugs Metabolism: An Update to Pharmacokinetic Profiles and Computational Approaches
Aikaterini Z
Current Pharmaceutical Design (2015)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service