C7869

CEP-701 hydrate

≥98% (HPLC)

• Synonym(s): KT-5555 hydrate, Lestaurtinib hydrate
• Empirical Formula (Hill Notation): C₂₆H₂₁N₃O₄ · xH₂O
• CAS Number: 111358-88-4
• Molecular Weight: 439.46 (anhydrous basis)
• MDL number: MFCD12828858
• UNSPSC Code: 12352200
• PubChem Substance ID: 329775153
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white
• solubility: DMSO: >10 mg/mL
• storage temp.: −20°C
• SMILES string: O.C[C@]12O[C@H](C[C@]1(O)CO)n3c4ccccc4c5c6C(=O)NCc6c7c8ccccc8n2c7c35
• InChI: 1S/C26H21N3O4.H2O/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28;/h2-9,18,30,32H,10-12H2,1H3,(H,27,31);1H2/t18-,25+,26+;/m1./s1
• InChI key: LPOQWFBZBJTLEO-GMEYHWBASA-N

Description

Application

CEP-701 hydrate has been used as a tyrosine kinase inhibitor:

• to study its effects on early growth response protein (EGR) genes and nerve growth factor (NGF) stimulation in human epithelial cells
• as a supplement in reservoir solution for co-crystallization studies with human receptor-interacting protein kinase 4 (RIPK4)
• as an FMS-like tyrosine kinase 3 (FLT3) inhibitor-gold nanoparticle conjugate to study its effects on acute myeloid leukemia

Biochem/physiol Actions

CEP-701 hydrate, also known as Lestaurtinib, can repress Janus kinase 2/signal transducer and activator of transcription 5 (JAK2/STAT5) signaling by the specific inhibition of JAK2.

CEP-701 is a Flt-3 receptor tyrosine kinase inhibitor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves