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B3876

Sigma-Aldrich

BICINE

≥99% (titration)

Synonym(s):

N,N-Bis(2-hydroxyethyl)glycine

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About This Item

Empirical Formula (Hill Notation):
C6H13NO4
CAS Number:
150-25-4
Molecular Weight:
163.17
Beilstein:
1769362
EC Number:
205-755-1
MDL number:
MFCD00004295
UNSPSC Code:
12161700
PubChem Substance ID:
24891738
NACRES:
NA.25

Quality Level

400

Assay

≥99% (titration)

form

powder or crystals

pH

3.5-5.0

useful pH range

7.6-9.0

pKa (25 °C)

8.3

solubility

water: 25 % (w/w), clear, colorless

application(s)

diagnostic assay manufacturing

storage temp.

room temp

SMILES string

OCCN(CCO)CC(O)=O

InChI

1S/C6H13NO4/c8-3-1-7(2-4-9)5-6(10)11/h8-9H,1-5H2,(H,10,11)

InChI key

FSVCELGFZIQNCK-UHFFFAOYSA-N

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Application

Recommended buffer for low temperature biochemical work. Used in the preparation of stable substrate solution for serum guanase determination. Spacer in plasma protein fractionation with Sephadex® by isotachophoresis.

Legal Information

Sephadex is a registered trademark of Cytiva

replaced by

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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T A Churchill et al.
Transplantation, 65(4), 551-559 (1998-03-21)
This study was designed to investigate the effects of a modified University of Wisconsin (UW) solution supplemented with one of four buffering agents (histidine, bicine [N,N-bis(2-hydroxyethyl)glycine], tricine [N-tris(hydroxymethyl)methylglycine], and Tris) on liver metabolism during cold ischemic storage. Rat livers were
B M Altura et al.
British journal of pharmacology, 69(2), 207-214 (1980-06-01)
1 In vitro studies were undertaken on rat aortic strips and portal vein segments in order to determine whether or not several commonly used artificial buffers, i.e., tris(hydroxymethyl) aminomethane (Tris), N-2-hydroxyethylpiperazine-N'-2-ethanesulphonic acid (HEPES), morpholine propanesulphonic acid (MOPS), N,N bis(2-hydroxyethyl) glycine
R Nakon et al.
Science (New York, N.Y.), 221(4612), 749-750 (1983-08-19)
Metal-ion affinity (formation) constants were determined for two "Good's" buffers, N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid (TES) and N,N-bis(2-hydroxyethyl)glycine (bicine). The metal chelates formed undergo loss of an internal ligand (alcohol) proton (bicine) and undergo hydrolysis (bicine and TES) and dimerization reactions (TES). Bicine
Oliver J Harrison et al.
Cell reports, 30(8), 2655-2671 (2020-02-27)
Non-clustered δ1- and δ2-protocadherins, close relatives of clustered protocadherins, function in cell adhesion and motility and play essential roles in neural patterning. To understand the molecular interactions underlying these functions, we used solution biophysics to characterize binding of δ1- and
R P Pulis et al.
American journal of physiology. Heart and circulatory physiology, 279(5), H2151-H2158 (2000-10-25)
We investigated the metabolic effects of buffering agents alpha-amino-4-imidazole-propionic acid (Histidine), N, N-bis(2-hydroxyethyl)glycine (bicine), N, N-bis(2-hydroxyethyl)-2-aminoethanesulfonic acid (BES) on anaerobic energy production (via glycolysis) and conservation of key regulatory enzyme activity, and phosphofructokinase (PFK) throughout prolonged hypothermic hypoxia in porcine
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Protocols

Recycling Micro-Assay of β-NAD and β-NADH

Objective: To standardize a procedure for the recycling micro-assay of β-NAD and β-NADH

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