Archives of animal nutrition, 67(2), 134-146 (2013-03-26)
Deoxynivalenol (DON) is one of the most important trichothecenes, due to its worldwide distribution and common contamination of animal feed. It mainly affects the gastrointestinal tract and the immune system with a high susceptibility for swine. Lipopolysaccharides (LPS) are endotoxins
The systemic effects of the Fusarium toxin deoxynivalenol (DON) and of bacterial lipopolysaccharides (LPS) were studied in male castrated pigs (40.4 ± 3.7 kg) infused intravenously with either DON or LPS alone (100 μg DON/kg/h, 7.5 μg/LPS/kg/h), or together (100
Consumption of the trichothecene deoxynivalenol (DON) suppresses growth in experimental animals - an adverse effect that was used to establish the tolerable daily intake for this toxin. DON ingestion has been recently found to suppress plasma insulin-like growth factor acid-labile
Toxicology and applied pharmacology, 268(2), 201-211 (2013-01-29)
Deoxynivalenol (DON), a trichothecene mycotoxin produced by Fusarium that commonly contaminates food, is capable of activating mononuclear phagocytes of the innate immune system via a process termed the ribotoxic stress response (RSR). To encapture global signaling events mediating RSR, we
Archives of animal nutrition, 67(1), 37-47 (2013-01-23)
Fusarium infections do not only affect the grain, but also the rest of the plant, which result in contamination of plants with the mycotoxin deoxynivalenol (DON). The bioavailability of DON may be influenced by the matrix due to the differences
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