33114

Citric acid monohydrate

puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., buffer substance, 99.5-102%

• Synonym(s): 2-hydroxy-1,2,3-propanetricarboxylic acid monohydrate
• Linear Formula: HOC(COOH)(CH₂COOH)₂ · H₂O
• CAS Number: 5949-29-1
• Molecular Weight: 210.14
• Beilstein: 4018641
• EC Number: 201-069-1
• MDL number: MFCD00149972
• UNSPSC Code: 12352100
• PubChem Substance ID: 57648756
• NACRES: NA.21

Properties

• grade: ACS reagent; puriss. p.a.
• Quality Level: 200
• Agency: USP/NF; reag. ISO; reag. Ph. Eur.
• Assay: 99.5-100.5% (calc. on anhydrous substance); 99.5-102%
• form: solid
• impurities: ≤0.005% insolubles in water; ≤2 ppm heavy metals (as Pb); 7.5-9.0% water (Karl Fischer)
• ign. residue: ≤0.01% (as SO₄)
• pKa: (1) 3.13, (2) 4.76, (3) 6.4
• anion traces: chloride (Cl^-): ≤5 mg/kg; oxalate (C₂O₄^2-): ≤50 ppm; phosphate (PO₄^3-): ≤10 mg/kg; sulfate (SO₄^2-): ≤20 ppm
• cation traces: Ca: ≤50 mg/kg; Cu: ≤5 mg/kg; Fe: ≤3 ppm; Pb: ≤2 ppm; Zn: ≤5 mg/kg
• suitability: complies for appearance of solution; complies for reaction against H₂SO₄
• SMILES string: OC(CC(O)(C(O)=O)CC(O)=O)=O.O
• InChI: 1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2
• InChI key: YASYEJJMZJALEJ-UHFFFAOYSA-N

Description

General description

Citric acid monohydrate is an organic acid. Its molar enthalpy of solution in water has been reported to be Δ_solH_m (298.15K, m = 0.0203molkg^-1) = (29061 ± 123)Jmol^-1.

Application

Citric acid monohydrate may be used in the preparation of tris-citrate buffer and Otto I isolation buffer used in bioprotocols. It may also be used to improve the release of diltiazem hydrochloride from melt extruded matrix tablets.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): 345.0 °F - closed cup
• Flash Point(C): 173.9 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves