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Key Documents

AB5449

Sigma-Aldrich

Anti-Tropomyosin 4 Antibody

serum, Chemicon®

Synonym(s):

Tm4

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse, rat

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NM_003290.1

UniProt accession no.

P67936

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... TPM4(7171)

Specificity

Recognizes Tropomyosin 4.

Immunogen

Synthetic peptide corresponding to the 9d exon from the delta gene of tropomyosin.

Application

Detect Tropomyosin 4 using this Anti-Tropomyosin 4 Antibody validated for use in WB, IC, IH.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J N Martin et al.
Neuroscience, 164(2), 563-572 (2009-08-12)
DYT1, the most common inherited dystonia, is caused by a common dominant mutation in the TOR1A gene that leads to a glutamic acid deletion in the protein torsinA. Wild-type torsinA locates preferentially in the endoplasmic reticulum while the disease-linked mutant
Sharissa L Latham et al.
Nature communications, 9(1), 4250-4250 (2018-10-14)
Germline mutations in the ubiquitously expressed ACTB, which encodes β-cytoplasmic actin (CYA), are almost exclusively associated with Baraitser-Winter Cerebrofrontofacial syndrome (BWCFF). Here, we report six patients with previously undescribed heterozygous variants clustered in the 3'-coding region of ACTB. Patients present
Irina Pleines et al.
The Journal of clinical investigation, 127(3), 814-829 (2017-01-31)
Platelets are anuclear cells that are essential for blood clotting. They are produced by large polyploid precursor cells called megakaryocytes. Previous genome-wide association studies in nearly 70,000 individuals indicated that single nucleotide variants (SNVs) in the gene encoding the actin
Andrius Masedunskas et al.
Journal of cell science, 131(6) (2018-03-01)
Many actin filaments in animal cells are co-polymers of actin and tropomyosin. In many cases, non-muscle myosin II associates with these co-polymers to establish a contractile network. However, the temporal relationship of these three proteins in the de novo assembly
Michael J Christie et al.
Physiological reports, 6(24), e13954-e13954 (2018-12-29)
Intrauterine growth restriction (IUGR) is known to alter vascular smooth muscle reactivity, but it is currently unknown whether these changes are driven by downstream events that lead to force development, specifically, Ca2+ -regulated activation of the contractile apparatus or a
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