655207

TWEEN^® 80

protein grade detergent, 10% solution, sterile-filtered, for immunoprecipitation and for the solubilization of membrane-bound proteins

• Synonym(s): TWEEN^® 80, Polysorbate 80, POE (20) sorbitan monooleate, Polyethylene glycol sorbitan monooleate, Polyoxyethylenesorbitan monooleate
• CAS Number: 9005-65-6
• MDL number: MFCD00082107
• UNSPSC Code: 12161902
• NACRES: NA.25

Properties

• description: Merck USA index - 14, 7582
• Quality Level: 100
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• aggregation number: 58
• impurities: ≤200 μM Aldehyde; ≤200 μM peroxide
• color: clear colorless
• CMC: 12 μM (HLB number 15)
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: CCCCCCCC/C=C/CCCCCCCC(=O)OCCOCC(C1C(CC(O1)OCCO)OCCO)OCCO
• InChI: 1S/C32H60O10/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-30(36)40-25-24-37-27-29(39-22-19-34)32-28(38-21-18-33)26-31(42-32)41-23-20-35/h9-10,28-29,31-35H,2-8,11-27H2,1H3/b10-9+
• InChI key: RGPBUVUVZKQNHD-MDZDMXLPSA-N

Description

General description

Conductivity:≤50 µmhos.

Non-ionic detergent used for immunoprecipitation and for the solubilization of membrane-bound proteins (aggregation number: 58; conductivity: <50 µmhos; CMC: 12 µM; HLB number: 15). Supplied as a 10% (W/W) solution of PROTEIN GRADE TWEEN 80 detergent.

Non-ionic detergent used for immunoprecipitation and for the solubilization of membrane-bound proteins. Supplied as a 10% (W/W) solution of PROTEIN GRADE TWEEN 80 detergent.

Application

• Performance of β-carotene-loaded nanostructured lipid carriers under dynamic in vitro digestion system: Influence of the emulsifier type.: This paper discusses the performance of β-carotene-loaded nanostructured lipid carriers, where TWEEN 80 is utilized as an emulsifier. The study highlights its impact on the stability and bioaccessibility of β-carotene during digestion, offering valuable insights for food science and nutraceuticals applications (Lüdtke FL et al., 2024).


• Fabrication and characterization of transdermal delivery of ribociclib nanoemulgel in breast cancer treatment.: This study explores the use of TWEEN 80 in developing a transdermal nanoemulgel for the delivery of ribociclib, enhancing its therapeutic efficacy against breast cancer. The work focuses on innovative drug delivery systems that improve patient compliance and drug stability (Makeen HA et al., 2024).


• A novel antifungal nanoemulsion based on reuterin-assisted synergistic essential oils: Preparation and in vitro/in vivo characterization.: Here, TWEEN 80 is used to create a potent antifungal nanoemulsion, incorporating reuterin and essential oils. The study emphasizes the potential of nanoemulsions to significantly enhance the antifungal activity of natural compounds, promising applications in food preservation and safety (Nikkhah M et al., 2024).


• Development and characterization of edible and active coating based on xanthan gum nanoemulsion incorporating betel leaf extract for fresh produce preservation.: This investigation uses TWEEN 80 in a xanthan gum-based nanoemulsion, integrating betel leaf extract for the preservation of fresh produce. It highlights the role of such nanoemulsions in extending the shelf life of perishable foods, with significant implications for the food industry (Aayush K et al., 2024).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Physical form

Supplied as a 10% (W/W) aqueous solution.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

PROTEIN GRADE is a registered trademark of Merck KGaA, Darmstadt, Germany

TWEEN is a registered trademark of Croda International PLC

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): >235.4 °F - closed cup
• Flash Point(C): > 113 °C - closed cup