840514P
Avanti
16:0-18:1 Phosphatidylethanol
Avanti Research™ - A Croda Brand 840514P, powder
Synonym(s):
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol (sodium salt)
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All Photos(2)
About This Item
Empirical Formula (Hill Notation):
C39H74NaO8P
CAS Number:
Molecular Weight:
724.96
UNSPSC Code:
12352211
NACRES:
NA.25
Recommended Products
Assay
>99% (TLC)
form
powder
packaging
pkg of 2 × 100 mg (840514P-200mg)
pkg of 1 × 25 mg (840514P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 840514P
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@@](COP([O-])(OCC)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O.[Na+]
General description
Phosphatidylethanol (PEth) is a phospholipid, that is generated in the presence of ethanol in cell membranes. PEths like PEth 16:0/18:1, PEth 18:1/18:1, and PEth 16:0/16:0 possesses a common phosphoethanol head. Two fatty acid chains of variable length and degree of saturation are bound to this head group.
Phosphatidylethanol (PEth) represents a group of glycerophospholipid homologues generated by substitution of ethanol for the lipid headgroup by the phospholipase D enzyme. Since the formation of PEth is specifically dependent on ethanol, the diagnostic specificity of PEth as an alcohol biomarker is theoretically 100%.
Application
16:0-18:1 Phosphatidylethanol may be used in surface planar bilayers (SPBs) formation.
Biochem/physiol Actions
Phosphatidylethanols (PEths) serves as crucial biomarkers of alcohol consumption.
Packaging
5 mL Clear Glass Sealed Ampule (840514P-200mg)
5 mL Clear Glass Sealed Ampule (840514P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
Certificates of Analysis (COA)
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Surface planar bilayers of phospholipids used in protein membrane reconstitution: an atomic force microscopy study
Domenech O, et al.
Colloids and Surfaces. B, Biointerfaces, 47(1), 102-106 (2006)
Alexandra Schröck et al.
Bioanalysis, 6(17), 2285-2294 (2014-11-11)
For early diagnosis and therapy of alcohol-related disorders, alcohol biomarkers are highly valuable. Concerning specificity, indirect markers can be influenced by nonethanol-related factors, whereas direct markers are only formed after ethanol consumption. Sensitivity of the direct markers depends on cut-offs
David Wensbo Posaric et al.
Analytical and bioanalytical chemistry, 406(19), 4735-4744 (2014-05-29)
Various phosphatidylethanol (PEth) derivatives, the corresponding reversed positional isomers (RPI-PEths), lyso-PEth-16:0, and penta-deuterium-labeled PEth analogs (d5-PEths), were synthesized by enzyme-independent synthetic routes. A general solvent system consisting of a mixture of acetone-d6 and methanol-d4 (97:3; v/v) was found to provide
The detection of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol and ethyl glucuronide in human umbilical cord
Jones J, et al.
American Journal of Analytical Chemistry, 3(12), 800-800 (2012)
Anders Isaksson et al.
Drug testing and analysis, 3(4), 195-200 (2011-03-26)
Phosphatidylethanol (PEth) represents a group of glycerophospholipid homologues where ethanol by phospholipase D has been bound at the position that normally contains an amino-alcohol. Since the formation of PEth is specifically dependent on ethanol, the diagnostic specificity of PEth as
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