Skip to Content
Merck
All Photos(2)

Key Documents

C4135

Sigma-Aldrich

Carbamyl phosphate disodium salt

≥80%

Synonym(s):

Disodium carbamyl phosphate

Sign Into View Organizational & Contract Pricing


About This Item

Linear Formula:
CH2NO5PNa2
CAS Number:
Molecular Weight:
184.98
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Assay

≥80%

form

powder

storage temp.

−20°C

SMILES string

[Na].NC(=O)OP(O)(O)=O

InChI

1S/CH4NO5P.2Na/c2-1(3)7-8(4,5)6;;/h(H2,2,3)(H2,4,5,6);;/q;2*+1/p-2

InChI key

ZZRCKSSPGJOTEE-UHFFFAOYSA-L

General description

Carbamyl phosphate disodium salt (CPC) is an important reagent in organic synthesis due to its ability to activate carboxylic acids and convert them to their corresponding mixed anhydrides. It is used in the synthesis of cyclic peptides and macrocycles by activating carboxylic acids and facilitating cyclization reactions.

Application

  • Carbamoyl phosphate and its substitutes for the uracil synthesis in origins of life scenarios: This study explores the role of carbamoyl phosphate disodium salt in the prebiotic synthesis of uracil, a fundamental component of RNA, under early Earth conditions (LMP Ter-Ovanessian et al., 2021).
  • Building the uracil skeleton in primitive ponds at the origins of life: carbamoylation of aspartic acid: Further investigations into the prebiotic significance of carbamoyl phosphate, demonstrating its potential to interact with aspartic acid to form uracil in early Earth scenarios (LMP Ter-Ovanessian, JF Lambert, MC Maurel, 2022).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Eduardo H Morales et al.
BMC microbiology, 12, 63-63 (2012-05-02)
Hydrogen peroxide (H2O2) and hypochlorous acid (HOCl) are reactive oxygen species that are part of the oxidative burst encountered by Salmonella enterica serovar Typhimurium (S. Typhimurium) upon internalization by phagocytic cells. In order to survive, bacteria must sense these signals
Dan M Park et al.
ACS synthetic biology, 8(4), 807-817 (2019-03-22)
The ability to detect uranium (U) through environmental monitoring is of critical importance for informing water resource protection and nonproliferation efforts. While technologies exist for environmental U detection, wide-area environmental monitoring, i.e. sampling coverage over large areas not known to
Amino acids downregulate SIRT4 to detoxify ammonia through the urea cycle
Hu Song-Hua, et al
Nature metabolism, 1-16 (2023)
P Guerrero et al.
Microbiology (Reading, England), 159(Pt 10), 2049-2057 (2013-08-07)
In response to antibiotics, bacteria activate regulatory systems that control the expression of genes that participate in detoxifying these compounds, like multidrug efflux systems. We previously demonstrated that the BaeSR two-component system from Salmonella enterica serovar Typhimurium (S. Typhimurium) participates

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service