L9793

LP44

≥98% (HPLC), solid

• Synonym(s): 4-[2-(Methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphth alenyl)-1-piperazinehexanamide hydrochloride
• Empirical Formula (Hill Notation): C₂₇H₃₈ClN₃OS
• CAS Number: 824958-12-5
• Molecular Weight: 488.13
• MDL number: MFCD09971090
• UNSPSC Code: 12352200
• PubChem Substance ID: 329817675
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• solubility: DMSO: >10 mg/mL; H₂O: ≥2 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.CSc1ccccc1N2CCN(CCCCCC(=O)NC3CCCc4ccccc34)CC2
• InChI: 1S/C27H37N3OS.ClH/c1-32-26-15-7-6-14-25(26)30-20-18-29(19-21-30)17-8-2-3-16-27(31)28-24-13-9-11-22-10-4-5-12-23(22)24;/h4-7,10,12,14-15,24H,2-3,8-9,11,13,16-21H2,1H3,(H,28,31);1H
• InChI key: DWGKCWWWKHCVDH-UHFFFAOYSA-N

Description

Application

LP44 has been used as a 5-hydroxytryptamine (serotonin) receptor 7 (5-HT7) agonist to study its effects on mitochondria-mediated leucine-rich repeat and pyrin domain containing 3 (NLRP3) inflammasome activation.

Biochem/physiol Actions

LP44 is a high affinity 5-HT₇ receptor agonist. K_i = 0.22 nM. LP44 displays selectivity over 5-HT_1A and 5-HT_2A receptors (200- and >1000-fold, respectively). LP44 induces relaxation of substance P-stimulated guinea pig ileum (EC₅₀ = 2.56 μM).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves