524394

4α-Phorbol-12,13-didecanoate

>99% (HPLC), solid, PDD and PMA negative control, Calbiochem^®

• Synonym(s): 4α-Phorbol-12,13-didecanoate, 4αPDD, PKC Activator I, Negative Control
• Empirical Formula (Hill Notation): C₄₀H₆₄O₈
• CAS Number: 27536-56-7
• Molecular Weight: 672.93
• MDL number: MFCD00036737
• UNSPSC Code: 12352211
• NACRES: NA.77

Properties

• product name: 4α-Phorbol-12,13-didecanoate, Inactive on mouse skin as an inflammatory and tumor-promoting agent.
• Quality Level: 100
• Assay: >99% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• solubility: DMSO: soluble; ethanol: soluble
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C40H64O8/c1-7-9-11-13-15-17-19-21-32(42)47-36-28(4)39(46)30(24-29(26-41)25-38(45)31(39)23-27(3)35(38)44)34-37(5,6)40(34,36)48-33(43)22-20-18-16-14-12-10-8-2/h23-24,28,30-31,34,36,41,45-46H,7-22,25-26H2,1-6H3/t28-,30+,31-,34-,36-,38+,39-,40-/m1/s1
• InChI key: DGOSGFYDFDYMCW-OEFRVDPMSA-N

Description

General description

Inactive on mouse skin as an inflammatory and tumor-promoting agent. Useful as a negative control for Phorbol-12,13-didecanoate (PDD; Cat. No. 524392) and Phorbol-12-myristate-13-acetate (PMA; Cat. No. 524400).

Reported to be inactive on mouse skin as an inflammatory and tumor-promoting agent. Used as a negative control for phorbol-12,13-didecanoate (PDD, Cat. No. 524392) and phorbol-12-myristate-13-acetate (PMA, Cat. No. 524400).

Biochem/physiol Actions

Cell permeable: no

Primary Target
A negative control for Phorbol-12,13-didecanoate (PDD) and Phorbol-12-myristate-13-acetate (PMA)

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Highly Toxic (H)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.

Other Notes

Akiguchi, I., et al. 1993. Endocrinology 138, 379.
Clarke, B.L., et al. 1993. Endocrinology132, 1168.
Natarajan, V. and Garcia, J.G. 1993. J. Lab. Clin. Med.121, 337.
Slomiany, B.L., et al. 1992. J. Physiol. Pharmacol.43, 223.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS06,GHS08,GHS05
• Signal Word: Danger
• Hazard Statements: H300 + H310 + H330,H314,H317,H334,H351
• Precautionary Statements: P201 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable