Skip to Content
Merck
All Photos(2)

Key Documents

900915

Sigma-Aldrich

N-Azidoacetylgalactosamine-tetraacylated

Synonym(s):

Ac4GalNAz

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C16H22N4O10
CAS Number:
Molecular Weight:
430.37
UNSPSC Code:
12352116
NACRES:
NA.22

form

powder or crystals

Quality Level

reaction suitability

reaction type: click chemistry

storage temp.

−20°C

Application

N-Azidoacetylgalactosamine-tetraacylated (Ac4GalNAz) provides the first part of a simple and robust two-step technique that helps identify and characterize cell surface sialic acid-containing glycoproteins. The azide-modified protein can be detected by reaction with alkynes. For example alkynes labeled with a fluorescent probe or a biotin can be used. The acetyl groups increase cell permeability and allow the unnatural sugars to easily pass through the cell membrane. Carboxyesterases remove the acetyl groups once the monosaccharide is in the cell.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Probing glycosyltransferase activities with the Staudinger ligation.
Hang H C, et al.
Journal of the American Chemical Society, 126(1), 6-7 (2004)
A chemoenzymatic approach toward the preparation of site-specific antibody?drug conjugates.
Cai X and Janda K D
Tetrahedron Letters, 56(23), 3172-3175 (2015)
Monitoring protein O-linked β-N-acetylglucosamine status via metabolic labeling and copper-free click chemistry.
Teo C F and Wells L
Analytical Biochemistry, 464, 70-72 (2014)

Articles

Choosing the right crosslinker for your biochemical or bioconjugation research can be challenging. Our selection guide can help you find the perfect match for your applications.

Choosing the right crosslinker for your biochemical or bioconjugation research can be challenging. Our selection guide can help you find the perfect match for your applications.

Choosing the right crosslinker for your biochemical or bioconjugation research can be challenging. Our selection guide can help you find the perfect match for your applications.

Choosing the right crosslinker for your biochemical or bioconjugation research can be challenging. Our selection guide can help you find the perfect match for your applications.

See All

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service