Journal of medicinal chemistry, 52(18), 5642-5648 (2009-08-28)
This study is aimed at the pharmacological exploitation of alpha-tocopheryl succinate (1) to develop potent antiadhesion agents. Considering the structural cooperativity between the phytyl chain and the carboxylic terminus in determining the antiadhesion activity, our structural optimization led to compound
Vitamin E succinate promotes breast cancer tumor dormancy
Malafa PM, et al.
The Journal of Surgical Research, 93(1), 163-170 (2000)
Metastasis is one of the major obstacles for the successful therapy of breast cancer. Although increased candidate drugs targeting cancer metastasis are tested, their clinical translation is limited by either serve toxicity or low efficacy. In present work, a nano-drug
International journal of pharmaceutics, 495(2), 792-797 (2015-09-28)
Our recent publication showed that VES-dFdC nanocapsules in pure water could be obtained via the self-assembling of VES-dFdC prodrug synthesized by coupling gemcitabine (dFdC) with vitamin E succinate (VES). To prepare the intravenous injection nanoformulation, we present here a novel
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