T3564
Tumor Necrosis Factor Soluble Receptor I (TNF sRI) from mouse
>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
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About This Item
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biological source
mouse
Quality Level
recombinant
expressed in E. coli
Assay
>97% (SDS-PAGE)
form
lyophilized powder
potency
0.5-1.5 μg/mL ED50
mol wt
21 kDa
packaging
pkg of 50 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Tnfrsf1a(21937)
Application
Tumor Necrosis Factor Soluble Receptor I (TNF sRI) from mouse plays a pivotal role in the signaling of apoptosis and NF-κB activation because of its “death domain” present at the intracellular portion.
Biochem/physiol Actions
Tumor Necrosis Factor Soluble Receptor I (TNF sRI) from mouse belongs to TNF family of receptors and has a pivotal role in neutralizing the biological activities of both TNF-α and TNF-β. Soluble tumor necrosis factor receptor along with intrathecal interleukin-1 receptor antagonist shows an anti-allodynic action in rat L5 spinal nerve transection model of neuropathic pain.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 2.5 mg bovine serum albumin
Analysis Note
The biological activity is measured by its ability to inhibit the recombinant mouse TNF-α mediated cytotoxicity in mouse L929 cells, in the presence of the metabolic inhibitor actinomycin D.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Matthews, N. et al. et al.
Lymphokines and Interferons, A Practical Approach, 221-221 (1987)
S Sweitzer et al.
Neuroscience, 103(2), 529-539 (2001-03-14)
The expression of interleukin-1beta and tumor necrosis factor has previously been shown to be up-regulated in the spinal cord of several rat mononeuropathy models. This present study was undertaken to determine whether blocking the action of central interleukin-1beta and tumor
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