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Key Documents

SAB5500164

Sigma-Aldrich

Anti-PLAP antibody, Rabbit monoclonal

recombinant, expressed in proprietary host, clone SP15, tissue culture supernatant

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

recombinant

expressed in proprietary host

conjugate

unconjugated

antibody form

tissue culture supernatant

antibody product type

primary antibodies

clone

SP15, monoclonal

species reactivity

human (tested)

technique(s)

immunohistochemistry: 1:100

isotype

IgG

UniProt accession no.

P05187

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... ALPP(250)

General description

Placental alkaline phosphatase (PLAP) or ALPP is a phosphomonoesterase. It is expressed in the placenta and endometrium. The PLAP gene is localized on human chromosome 2q37.1.

Immunogen

Recombinant protein encoding human placental alkaline phosphatase.

Biochem/physiol Actions

Placental alkaline phosphatase (PLAP) or ALPP is a hydrolase, which is involved in the hydrolysis of phosphomonoesters. It has been shown to be a biomarker for ovarian cancer. The protein is expressed in carcinomas such as ovarian adenocarcinoma, dysgerminoma, serous cystadenocarcinoma and undifferentiated carcinoma.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

0.1 ml rabbit monoclonal antibody supplied as tissue culture supernatant in TBS/1% BSA buffer pH 7.5 with less than 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Human placental alkaline phosphatase-mediated hydrolysis correlates tightly with the electrostatic contribution from tail group.
Yang Y
Chemical Biology & Drug Design (2011)
Genome wide expression profile in human HTR-8/Svneo trophoblastic cells in response to overexpression of placental alkaline phosphatase gene.
Bellazi L
Placenta (2011)
A human monoclonal antibody specific to placental alkaline phosphatase, a marker of ovarian cancer.
Ravenni N
MAbs (2014)
Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.
Stec B
Acta Crystallographica Section F, Structural Biology and Crystallization Communications (2010)
Cloverleaf skull anomaly and de novo
trisomy 4p
Journal of medical Genetics (1999)

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