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Key Documents

SAB4301605

Sigma-Aldrich

Anti-IL3RA

affinity isolated antibody

Synonym(s):

CD123, IL3R, IL3RAY, IL3RX, IL3RY

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

species reactivity

human, mouse

technique(s)

immunohistochemistry: 1:100-1:200
western blot: 1:500-1:2000

accession no.

NP_002174

UniProt accession no.

P26951

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IL3RA(3563)

General description

Interleukin 3 receptor subunit α alpha (IL3RA or CD123) gene is localized in the X and Y chromosomes. It comprises a highly mobile N-terminal domain (NTD) region and fibronectin type III (FnIII) domain. CD123 is expressed on early hematopoietic cells and is a type I cytokine receptor.

Immunogen

Synthetic peptide of human interleukin 3 receptor, alpha (low affinity)

Biochem/physiol Actions

Elevated expression of IL3RA is reported in chronic myeloid leukemia (CML).) It may serve as a therapeutic potential to treat acute myelogenous leukemia (AML).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M Joseph et al.
Journal of medical genetics, 33(11), 906-911 (1996-11-01)
Colony stimulating factor-2 receptor alpha (CSF2RA) and interleukin-3 receptor alpha (IL3RA), two genes from the chromosome Xp and Yp pseudoautosomal region (PAR), have been suggested as candidate genes for short stature in Turner syndrome. We report three girls with X;Y
C T Jordan et al.
Leukemia, 14(10), 1777-1784 (2000-10-06)
Recent studies suggest that the population of malignant cells found in human acute myelogenous leukemia (AML) arises from a rare population of leukemic stem cells (LSCs). LSCs have been documented for nearly all AML subtypes and have been phenotypically described
Prognostic relevance of CD123 expression in adult AML with normal karyotype.
Gina Jiang et al.
British journal of haematology, 188(1), 181-184 (2019-11-24)
Sophie E Broughton et al.
Nature communications, 9(1), 386-386 (2018-01-28)
The interleukin-3 (IL-3) receptor is a cell-surface heterodimer that links the haemopoietic, vascular and immune systems and is overexpressed in acute and chronic myeloid leukaemia progenitor cells. It belongs to the type I cytokine receptor family in which the α-subunits

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