SAB3500438

Anti-CLDN1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-CLD1, Anti-CLDN1, Anti-Claudin 1, Anti-ILVASC, Anti-SEMP1
• MDL number: MFCD02096101
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: rat, mouse, human
• technique(s): immunocytochemistry: suitable; immunofluorescence: suitable; indirect ELISA: suitable; western blot: suitable
• NCBI accession no.: CAG33419
• UniProt accession no.: O95832
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CLDN1(9076)

Description

General description

Claudin 1 (CLDN1) is a component of tight junctions. It is part of the transmembrane tight junction protein family. The CLDN1 gene is localized on human chromosome 3q28.

Immunogen

CLDN1 antibody was raised against a 20 amino acid peptide near the carboxyl terminus of human CLDN1.

Biochem/physiol Actions

Claudin 1 (CLDN1) has a role in epithelial-mesenchymal transition. It is a sealing and tightening junctional protein. CLDN1 has been shown to be downregulated in lung adenocarcinoma. Mutations in this gene have also been linked to neonatal ichthyosis and sclerosing cholangitis.

Features and Benefits

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Linkage

The action of this antibody can be blocked using blocking peptide SBP3500438.

Physical form

Supplied in PBS with 0.02% sodium azide.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable