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M2295

Myelin Basic Protein from guinea pig brain

≥80% (SDS-PAGE), lyophilized powder, from guinea pig brain

Synonym(s):

MBP

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
MFCD00131640
Form:
lyophilized powder
Assay:
≥80% (SDS-PAGE)
Biological source:
guinea pig brain
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biological source

guinea pig brain

Quality Segment

assay

≥80% (SDS-PAGE)

form

lyophilized powder

technique(s)

cell based assay: suitable

UniProt accession no.

application(s)

cell analysis

storage temp.

−20°C

Gene Information

guinea pig ... MBP(100731253)

General description

Myelin Basic Protein (MBP) expressed in guinea pig brain contains 167 amino acids and has a molecular weight of 18,256Da.
Research area: Cell SignallingMyelin basic protein (MBP) is an important constituent of the myelin sheath of CNS (central nervous system). It is an auto-immunogen.

Application

Myelin Basic Protein fromguinea pig brain has been used as a kinase substrate: to analyse in vitrokinase activity, in protein phosphorylation analysis, in ATG1 kinaseassay

Biochem/physiol Actions

Major structural protein of CNS myelin. Used to induce experimental allergic encephalomyelitis.
Mutation of the myelin basic protein gene induces dysmyelination; used to induce experimental allergic encephalomyelitis.
Used as a kinase substrate.
Myelin basic protein (MBP) plays a vital role in formation of myelin sheath and is associated with the various neurological disorders. MBP function as an antigenic target in autoimmune disease experimental allergic encephalomyelitis (EAE). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositides and regulation of calcium homoeostasis. MBP functions as an in vitro substrate for mitogen-activated protein kinase (MAP) kinase and aids in the purification and functional studies of enzyme.

Analysis Note

May contain traces of urea-glycine buffer salts.

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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