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Bay 11-7085

Name: Bay 11-7085
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

(E)-3-(4-t-Butylphenylsulfonyl)-2-propenenitrile

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₅NO₂S

CAS Number:

196309-76-9

Molecular Weight:

249.33

NACRES:

NA.77

PubChem Substance ID:

24278273

UNSPSC Code:

12352200

MDL number:

MFCD01862602

Assay:

≥98% (HPLC)

Form:

solid

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: soluble >25 mg/mL, H₂O: insoluble

SMILES string

CC(C)(C)c1ccc(cc1)S(=O)(=O)\C=C\C#N

InChI

1S/C13H15NO2S/c1-13(2,3)11-5-7-12(8-6-11)17(15,16)10-4-9-14/h4-8,10H,1-3H3/b10-4+

InChI key

VHKZGNPOHPFPER-ONNFQVAWSA-N

Gene Information

human ... NFKB1(4790)

Description

Application

Bay 11-7085 has been used as:

nuclear factor-κB inhibitor in Panc-1 cells, macrophages
inhibitory κB kinase IKK inhibitor in human astrocytoma cells U87MGs
phospho-p65 inhibitor human monocyte cell line THP-1

Biochem/physiol Actions

Inhibits NF-κB activated expression of ICAM-1, VCAM-1, E-selectin, IL-6 and IL-8.

Bay 11-7085 inactivates peroxisome proliferator-activated receptors γ (PPAR-γ) and increases the microtubule-associated proteins 1A/1B light chain 3B (LC3B), a marker of autophagy resulting in apoptosis in human synovial fibroblasts. It promotes apoptosis in pancreatic carcinoma and may serve as radiotherapy-sensitizing drug. BAY 11-7085 decreases B-cell lymphoma 2 (Bcl-2) by inhibiting pI-κBα (inhibitor of nuclear factor κ B kinase subunit α

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This Item	B5556	196870	O2378
Sigma-Aldrich B5681 Bay 11-7085	Sigma-Aldrich B5556 Bay 11-7082	Sigma-Aldrich 196870 BAY 11-7082	Sigma-Aldrich O2378 Oxymetazoline hydrochloride
description ≥98% (HPLC), solid	description ≥98% (HPLC), powder	description The BAY 11-7082, also referenced under CAS 19542-67-7, controls the biological activity of TNF-α. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.	description ≥99%, solid
form solid	form powder	form solid	form solid
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥99%
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
solubility DMSO: soluble >25 mg/mL, H₂O: insoluble	solubility H₂O: insoluble, DMSO: >20 mg/mL	solubility DMSO: 200 mg/mL	solubility alcohol: soluble, H₂O: soluble
color white	color white	color off-white	color -
Gene Information human ... NFKB1(4790)	Gene Information -	Gene Information -	Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), HTR1A(3350), HTR1B(3351), HTR1D(3352)

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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