This product is intended for research use only and not suitable for human or veterinary use. This material is not tested for in vivo or in vitro applications. However, there are available publications referencing this compound being used successfully in animal models. Please see the link below to review an example of one such paper:
https://www.sciencedirect.com/science/article/pii/S2211124719300671?via%3Dihub
A5602
AMD3100 octahydrochloride hydrate
≥97% (NMR), solid, CXCR4 antagonist
Synonym(s):
1,1′-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride, JM3100, Plerixafor, SID791
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All Photos(2)
About This Item
Empirical Formula (Hill Notation):
C28H54N8 · 8HCl · xH2O
CAS Number:
Molecular Weight:
794.47 (anhydrous basis)
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
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Product Name
AMD3100 octahydrochloride hydrate, ≥97% (NMR), solid
Quality Level
Assay
≥97% (NMR)
form
solid
storage condition
desiccated
solubility
H2O: ≥10 mg/mL, clear
originator
Sanofi Aventis
storage temp.
−20°C
SMILES string
Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].[H]O[H].C1CNCCNCCCN(CCNC1)Cc2ccc(CN3CCCNCCNCCCNCC3)cc2
InChI
1S/C28H54N8.8ClH.H2O/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36;;;;;;;;;/h5-8,29-34H,1-4,9-26H2;8*1H;1H2
InChI key
GKFHDCZYJHUPEN-UHFFFAOYSA-N
Application
AMD3100 is a highly specific chemokine receptor CXCR4 antagonist. AMD3100 has been used in a study to determine the blockade of CXCR4 in oral squamous cell carcinoma and inhibition of lymph node metastases.
Biochem/physiol Actions
AMD3100 is a highly specific chemokine receptor CXCR4 antagonist.
Features and Benefits
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Customers Also Viewed
Daniele Biasci et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(46), 28960-28970 (2020-11-01)
Inhibition of the chemokine receptor CXCR4 in combination with blockade of the PD-1/PD-L1 T cell checkpoint induces T cell infiltration and anticancer responses in murine and human pancreatic cancer. Here we elucidate the mechanism by which CXCR4 inhibition affects the
Yonghua Xue et al.
Molecular medicine reports, 22(4), 2767-2774 (2020-09-19)
The hypoxic state of the brain tissue surrounding craniocerebral injury induces an increase in the secretion of HIF‑1α during the healing process. HIF‑1α can promote mesenchymal stem cell (MSC) migration to ischemic and hypoxic sites by regulating the expression levels
Imadeldin Yahya et al.
Scientific reports, 10(1), 5049-5049 (2020-03-21)
The present study shows that the CXCR4/SDF-1 axis regulates the migration of second branchial arch-derived muscles as well as non-somitic neck muscles. Cxcr4 is expressed by skeletal muscle progenitor cells in the second branchial arch (BA2). Muscles derived from the
David H McDermott et al.
Blood, 123(15), 2308-2316 (2014-02-14)
Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a rare immunodeficiency disorder caused by gain-of-function mutations in the G protein-coupled chemokine receptor CXCR4. The CXCR4 antagonist plerixafor, which is approved by the US Food and Drug Administration (FDA) for stem
Kelli P A MacDonald et al.
Journal of immunology (Baltimore, Md. : 1950), 192(7), 3180-3189 (2014-03-04)
The majority of allogeneic stem cell transplants are currently undertaken using G-CSF mobilized peripheral blood stem cells. G-CSF has diverse biological effects on a broad range of cells and IL-10 is a key regulator of many of these effects. Using
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is this pharmaceutical grade for use in vivo? cat A5602-5mg AMD3100
1 answer-
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What is the solubility of Product A5602, AMD3100 octahydrochloride hydrate?
1 answer-
AMD3100 octahydrochloride hydrate is soluble in water at 22 mg/ml.
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Can solutions of Product A5602, AMD3100 octahydrochloride hydrate, be stored?
1 answer-
Sigma-Aldrich has not evaluated the solution stability of A5602. If no information on the solution stability is found from a literature search, we would recommend that that you prepare solutions fresh.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What biological effects has been reported for Product A5602, AMD3100 octahydrochloride hydrate?
1 answer-
This is a highly specific chemokine receptor CXCR4 antagonist. CXCR4 has been implicated in inflammation, cancer, and HIV infection.
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