Product H5534 is tested and recommended for cell culture applications. Product 56250 has not been tested for the suitability of cell culture and would need to be validated by the end-user.
56250
trans-4-Hydroxy-L-proline
≥99.0% (NT), BioXtra
Synonym(s):
(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid, Hyp
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About This Item
Empirical Formula (Hill Notation):
C5H9NO3
CAS Number:
Molecular Weight:
131.13
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
200-091-9
MDL number:
Beilstein/REAXYS Number:
81441
Pricing and availability is not currently available.
Product Name
trans-4-Hydroxy-L-proline, BioXtra, ≥99.0% (NT)
product line
BioXtra
Quality Segment
assay
≥99.0% (NT)
form
solid
optical activity
[α]20/D −76.0±1.5°, c = 5% in H2O
impurities
≤0.3% foreign amino acids
ign. residue
≤0.1% (as SO4)
loss
≤0.1% loss on drying, 110 °C
color
colorless to white
mp
273 °C (dec.) (lit.)
anion traces
chloride (Cl-): ≤100 mg/kg, sulfate (SO42-): ≤100 mg/kg
cation traces
Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤50 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, NH4+: ≤100 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤5 mg/kg
application(s)
peptide synthesis
SMILES string
O[C@H]1CN[C@@H](C1)C(O)=O
InChI
1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
InChI key
PMMYEEVYMWASQN-DMTCNVIQSA-N
Biochem/physiol Actions
Trans-4-Hydroxy-L-proline is used as a starting material in the synthesis of (-)-secrinine; the synthesis of prolinol-based nucleotide analogues with N-phosphonomethyl moiety attached to the nitrogen atom of prolinol ring and in asymmetric synthesis of the ABC-ring system of the antitumor antibiotic MPC1001.
Trans-4-Hydroxy-L-proline is used in the organic synthesis of depsilairdin analogues, noncompetitive peptidomimetic inhibitors of multidrug resistance P-glycoprotein and 3-guaninyl-5-hydroxymethyl-2-pyrrolidinone (4) or 3-adeninyl-5-hydroxymethyl-2-pyrrolidinone (5) nucleoside analogues.
Other Notes
Enzymes and intermediates of hydroxyproline degradation
Natural constituent of animal structural proteins such as collagen and elastin.
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This Item | |||
|---|---|---|---|
| form solid | form crystalline | form - | form - |
| assay ≥99.0% (NT) | assay ≥98.5% | assay ≥99% (TLC) | assay - |
| product line BioXtra | product line BioReagent | product line - | product line - |
| optical activity [α]20/D −76.0±1.5°, c = 5% in H2O | optical activity - | optical activity - | optical activity - |
| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level 300 |
| impurities ≤0.3% foreign amino acids | impurities endotoxin, tested | impurities - | impurities - |
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Storage Class
11 - Combustible Solids
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we need to use this component for cell culture. Is 56250 suitable (BioXtra, ≥99.0% (NT)) or we need to order the H5534 (BioReagent, suitable for cell culture, ≥98.5%)
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