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D8809
Daunorubicin hydrochloride
meets USP testing specifications
Synonym(s):
Daunomycin hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C27H29NO10 · HCl
CAS Number:
Molecular Weight:
563.98
Beilstein:
4229221
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.21
Pricing and availability is not currently available.
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Agency
USP/NF
meets USP testing specifications
Quality Level
form
solid
antibiotic activity spectrum
neoplastics
Mode of action
DNA synthesis | interferes
storage temp.
2-8°C
SMILES string
Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O
InChI
1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1
InChI key
GUGHGUXZJWAIAS-QQYBVWGSSA-N
Gene Information
human ... TOP2A(7153)
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Biochem/physiol Actions
Naturally fluorescent anthracycline antibiotic, anticancer drug. Substrate for Pgp, MRP-1 and BCRP. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes. Daunorubicin is sequestered into lysosomes according to a pH partitioning type mechanism.[1][2] Strong inhibitor of DNA and RNA synthesis.
Potent anticancer agent. Inhibits DNA and RNA synthesis as sequence specific ds-DNA intercalating agent.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral - Carc. 2 - Muta. 2 - Repr. 1B
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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What is the Department of Transportation shipping information for this product?
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What factors affect the stability of Product No. D8809, Daunorubicin hydrochloride, in solution?
1 answer-
Per Martindale The Extra Pharmacopoeia, 31st edition, p. 565-3 (1996), stability in solution appeared to be partly related to pH. Daunorubicin was more stable as the pH of the mixture became more acidic, with the best stability in glucose injection solution (5%) with a pH of 4.5 Although daunorubicin solutions are degraded by light, the effect is reported not to be significant at concentrations of 500 ug/mL or above. However, below this concentration, precautions should be taken to protect solutions from light, and storage should be in polyethylene or polypropylene containers to minimize adsorptive losses.
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Does Product No. D8809, Daunorubicin hydrochloride, have an expiration date?
1 answer-
Yes, each lot of this product will have an expiration date, and this date (month and year) can be found on the certificate of analysis for the lot.
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Does the assay information on the certificate of analysis for Product No. D8809, Daunorubicin hydrochloride, pertain to a "dry" or "as is" basis?
1 answer-
The assay information on the certificate of analysis is for the product "as is".
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What is this compound soluble in?
1 answer-
Per Martindale The Extra Pharmacopoeia, 31st edition, p. 565-3 (1996), this compound is freely soluble in water and methyl alcohol. It is slightly soluble in alcohol, very slightly soluble in chloroform, and practically insoluble in acetone.
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