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JAK3 Inhibitor II

Name: JAK3 Inhibitor II
Brand: MM

The JAK3 Inhibitor II, also referenced under CAS 211555-04-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

JAK3 Inhibitor II, 4-[(3ʹ-Bromo-4ʹ-hydroxyphenyl)amino]-6,7-dimethoxyquinazoline, WHI-P154

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₄BrN₃O₃

CAS Number:

211555-04-3

Molecular Weight:

376.20

MDL number:

MFCD02179366

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥97% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Properties

Quality Segment

100

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

pale yellow

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

Brc1c(ccc(c1)Nc2ncnc3c2cc(c(c3)OC)OC)O

InChI

1S/C16H14BrN3O3/c1-22-14-6-10-12(7-15(14)23-2)18-8-19-16(10)20-9-3-4-13(21)11(17)5-9/h3-8,21H,1-2H3,(H,18,19,20)

InChI key

CBIAKDAYHRWZCU-UHFFFAOYSA-N

Description

General description

A potent, cell-permeable, reversible, ATP-competitive, and specific inhibitor of JAK3 (IC₅₀ = 5.6 µM). Has no effect on either JAK1 or JAK2. Has also been shown to prevent the ionizing radiation-induced activation of c-Jun in DT-40 cells. Also acts as a potent inhibitor of glioblastoma cell adhesion and migration.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
JAK-3

Product competes with ATP.

Reversible: yes

Target IC₅₀: 5.6 µM against JAK3

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ghosh, S., et al. 2001. Acta Crystallogr. C.57, 76.
Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
Narla, R.K., et al. 1998. Clin Cancer Res.4, 2463.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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This Item	420126	SAB1403999	HPA070314
Sigma-Aldrich 420104 JAK3 Inhibitor II	Sigma-Aldrich 420126 JAK3 Inhibitor VI	Sigma-Aldrich SAB1403999 Monoclonal Anti-JAK3 antibody produced in mouse	Sigma-Aldrich HPA070314 Anti-JAK3 antibody produced in rabbit
description The JAK3 Inhibitor II, also referenced under CAS 211555-04-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.	description The JAK3 Inhibitor VI, also referenced under CAS 856436-16-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.	description clone 2A5, purified immunoglobulin, buffered aqueous solution	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
assay ≥97% (HPLC)	assay ≥98% (HPLC)	assay -	assay -
form solid	form solid	form buffered aqueous solution	form buffered aqueous glycerol solution
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename -	manufacturer/tradename -
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. −20°C
solubility DMSO: 100 mg/mL	solubility water: 1 mg/mL, DMSO: 5 mg/mL	solubility -	solubility -

Storage Class

11 - Combustible Solids

WGK

WGK 3

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