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SML0665

Sigma-Aldrich

LY-456236

≥98% (HPLC)

Synonym(s):

(4-Methoxy-phenyl)-(6-methoxy-quinazolin-4-yl)-amine hydrochloride, 6-Methoxy-N-(4-methoxyphenyl)-4-quinazolinamine hydrochloride, LY456236, MPMQ

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About This Item

Empirical Formula (Hill Notation):
C16H15N3O2 · HCl
CAS Number:
338736-46-2
Molecular Weight:
317.77
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

InChI

1S/C16H15N3O2.ClH/c1-20-12-5-3-11(4-6-12)19-16-14-9-13(21-2)7-8-15(14)17-10-18-16;/h3-10H,1-2H3,(H,17,18,19);1H

InChI key

AVKFOWUSTVWZQN-UHFFFAOYSA-N

Biochem/physiol Actions

LY-456236 is a selective mGlu1 receptor antagonist with an IC50 value of 143 nM for mGlu1 compared to > 10 μM for mGlu5 receptors.

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H302,H315,H318,H335,H413

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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