SAB5500153

Anti-N-RAS antibody, Rabbit monoclonal

clone SP174, recombinant, expressed in proprietary host, affinity isolated antibody

• Synonym(s): Anti-ALPS4, Anti-CMNS, Anti-KRAS, Anti-N-ras, Anti-NCMS, Anti-NRAS1, Anti-NS6
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• recombinant: expressed in proprietary host
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: SP174, monoclonal
• species reactivity: human (tested)
• technique(s): immunoblotting: 1:400; immunohistochemistry: 1:100
• isotype: IgG
• UniProt accession no.: P01111
• shipped in: wet ice
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: human ... NRAS(4893)

Description

General description

GTPase N-Ras or N-Ras is a guanine-nucleotide binding protein. Receptor tyrosine kinases and G-protein-coupled receptors activate Ras, which then stimulates the MAPK signal pathway. Point mutations (Q61R) in Ras prevent the GAP-mediated inhibition of the MAPK pathway in certain cancers such as lung carcinoma and melanoma. Abnormal MAPK signaling may lead to uncontrolled cell proliferation, resistance to both apoptosis and cancer therapy.

Immunogen

Synthetic peptide of human N-Ras protein containing N-Ras (Q61R) point mutation.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable