SAB4702015

Monoclonal Anti-CD103 FITC produced in mouse

• Synonym(s): ITGAE, Integrin alpha E
• UNSPSC Code: 12352203

Properties

• conjugate: FITC conjugate
• Quality Level: 100
• antibody product type: primary antibodies
• clone: Ber-ACT8, monoclonal
• form: buffered aqueous solution
• species reactivity: human, ( Non-human primates)
• technique(s): flow cytometry: suitable
• isotype: IgG1κ
• UniProt accession no.: P38570
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: human ... ITGAE(3682)

Description

General description

CD103 / integrin alphaE is an integrin subunit that is expressed on intraepithelial lymphocytes, epithelial dendritic cells, lamina propria-derived dendritic cells, a subpopulation of lamina propria T cells, a small subset of peripheral lymphocytes, namely T reg cells, and on activated and TGF-beta stimulated lymphocytes. CD103 is in mature form cleaved into two disulfide-linked chains (C-terminal 150 kDa chain and N-terminal 25 kDa chain). It heterodimerizes with integrin beta7 subunit to form alphaE/beta7 integrin (mucosal lymphocyte 1 antigen), which through binding E-cadherin mediates homing of lymphocytes to the intestinal epithelium, and, in addition to the role in adhesion, may serve as an accessory molecule for intraepithelial lymphocyte activation.

Specificity

The mouse monoclonal antibody Ber-ACT8 recognizes an extracellular epitope of CD103 (alpha E integrin), a type I transmembrane glycoprotein primarily found on intestinal intraepithelial lymphocytes.

Immunogen

HTLV-1 induced human T cell line MAPS16

Physical form

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preparation Note

Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Storage and Stability

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Other Notes

The antibody solution should be gently mixed before use.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable