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Key Documents

PRS4553

Sigma-Aldrich

Anti-Unc93b antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Unc-93 homolog B1 (C. elegans), Anti-Unc93b1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, human, mouse

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

Q9H1C4

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... UNC93B1(81622)

Related Categories

General description

Unc93b (unc-93 homolog B1) is a multiple membrane-spanning protein, that is located in the endoplasmic reticulum. It is mainly present in the heart and also highly expressed in dendritic cells and macrophages. It is located on chromosome 11q13.

Immunogen

a 19 amino acid peptide from near the amino-terminus of human Unc93b.

Biochem/physiol Actions

Unc93b (unc-93 homolog B1) plays an important role in controlling the activation of TLRs (toll-like receptors). It also participates in the localization of TLR3 (toll-like receptor 3) to the surface of cell.

Linkage

The action of this antibody can be blocked using blocking peptide SBP4553.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Description
Pricing

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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hUNC-93B1, a novel gene mainly expressed in the heart, is related to left ventricular diastolic function, heart failure morbidity and mortality in elderly men
Arnlov J, et al.
European Journal of Heart Failure, 7(6), 958-965 (2005)
Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing
Fukui R, et al.
The Journal of Experimental Medicine, 206(6), 1339-1350 (2009)
The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists
Pohar J, et al.
The Journal of Biological Chemistry, 288(1), 442-454 (2013)
Assessing the function of human UNC-93B in Toll-like receptor signaling and major histocompatibility complex II response
Koehn J, et al.
Human immunology, 68(11), 871-878 (2007)
hUNC93B1: a novel human gene representing a new gene family and encoding an unc-93-like protein
Kashuba VI, et al.
Gene, 283(1-2), 209-217 (2002)
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