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P9018

Sigma-Aldrich

Phorbol 12,13-didecanoate

solid

Synonym(s):

PDD, Phorbol 12,13-dicaprinate

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About This Item

Empirical Formula (Hill Notation):
C40H64O8
CAS Number:
24928-17-4
Molecular Weight:
672.93
Beilstein:
6036113
MDL number:
MFCD00065449
UNSPSC Code:
12352200
PubChem Substance ID:
24899003

form

solid

color

white

solubility

DMSO: soluble
ethanol: soluble
methanol: soluble

storage temp.

−20°C

SMILES string

[H][C@@]12C=C(CO)C[C@]3(O)C(=O)C(C)=C[C@@]3([H])[C@@]1(O)[C@H](C)[C@@H](OC(=O)CCCCCCCCC)[C@]4(OC(=O)CCCCCCCCC)C2C4(C)C

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General description

More potent than phorbol myristate acetate as an inflammatory agent, but weaker as a tumor promoting agent

Biochem/physiol Actions

Strong NO promoter; potent activator of protein kinase C; promotes iNOS expression in cultured hepatocytes.

Caution

Photosensitive

Reconstitution

A stock solution cannot be made in aqueous media; dissolve in a water-miscible organic solvent before dilution to working concentrations in aqueous media.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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