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M0883

Sigma-Aldrich

4-Methylumbelliferyl acetate

esterase substrate

Synonym(s):

MU-Ac

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About This Item

Empirical Formula (Hill Notation):
C12H10O4
CAS Number:
2747-05-9
Molecular Weight:
218.21
Beilstein:
189667
EC Number:
220-386-6
MDL number:
MFCD00006865
UNSPSC Code:
12352204
PubChem Substance ID:
24896576
NACRES:
NA.32

Assay

≥98% (TLC)

form

powder

mp

149-150 °C (lit.)

solubility

chloroform: 100 mg/mL, clear, colorless

fluorescence

λex 312 nm in methanol
λex 360 nm; λem 499 nm (Reaction product)

storage temp.

−20°C

SMILES string

CC(=O)Oc1ccc2C(C)=CC(=O)Oc2c1

InChI

1S/C12H10O4/c1-7-5-12(14)16-11-6-9(15-8(2)13)3-4-10(7)11/h3-6H,1-2H3

InChI key

HXVZGASCDAGAPS-UHFFFAOYSA-N

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Abha Kathuria et al.
Bioorganic & medicinal chemistry, 17(4), 1550-1556 (2009-02-03)
Calreticulin Transacetylase (CRTAase) catalyzes the transfer of acetyl groups from polyphenolic acetates (PAs) to the receptor proteins and modulates their biological activities. CRTAase was conveniently assayed by the irreversible inhibition of cytosolic glutathione S-transferase (GST) by the model acetoxycoumarin, 7,8-diacetoxy-4-methylcoumarin
M L Graber et al.
The American journal of physiology, 250(1 Pt 2), F159-F168 (1986-01-01)
Intracellular pH (pHi) of turtle bladder mucosal cells was studied by the trapped fluorescent indicator technique. Bladders efficiently accumulated and converted 4-methylumbelliferyl acetate to its pH-sensitive derivative 4-methylumbelliferone (4MU). Excited at the pH-indifferent wavelength 334 nm, bladders fluoresced a uniform
H A Berman et al.
Biochemistry, 29(47), 10640-10649 (1990-11-27)
This paper examines covalent reactivity of AchE with respect to cationic and uncharged methylphosphonates and substrates in the absence and presence of cationic ligands selective for the active center and the peripheral anionic site. The organophosphorus inhibitors are enantiomeric alkyl
Latent blue and red fluorophores based on the trimethyl lock.
Luke D Lavis et al.
Chembiochem : a European journal of chemical biology, 7(8), 1151-1154 (2006-06-07)
H G Raj et al.
Teratogenesis, carcinogenesis, and mutagenesis, 21(2), 181-187 (2001-02-27)
Our earlier studies documented the ability of 7,8-diacetoxy-4-methylcoumarin (DAMC) to cause irreversible inhibition of cytochrome P-450 linked mixed function oxidases (MFO) mediated by membrane bound DAMC: protein transacetylase. Since P-450 catalyzed oxidation of benzene is crucial to its toxic effects
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