E4154
Anti-EMMPRIN antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-CD147, Anti-Extracellular Matrix Metalloproteinase Inducer
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About This Item
biological source
goat
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
mouse
technique(s)
indirect ELISA: 0.5-1.0 μg/mL
western blot: 0.1-0.2 μg/mL
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
mouse ... Bsg(12215)
General description
Extracellular matrix metalloproteinase inducer (EMMPRIN) or cluster of differentiation 147 (CD147) is a protein encoded by the BSG gene in humans. It is also known as Basigin (BSG). It is a widely expressed plasma membrane protein that has been implicated in a variety of physiological and pathological activities. Expression of CD147 is significantly higher in ectopic endometrial tissues in patients with endometriosis compared to normal endometrial tissues.
Immunogen
purified recombinant mouse extracellular matrix metalloproteinase inducer extracellular domain (amino acids 22-209), expressed in NSO cells.
Application
Anti-EMMPRIN antibody produced in goat is suitable for western blotting at a concentration of 0.1-0.2μg/mL and indirect ELISA at a concentration of 0.5-1.0μg/mL.
Biochem/physiol Actions
CD147 functions as an extracellular matrix metalloproteinase inducer, regulates lymphocyte responsiveness, monocarboxylate transporter expression and spermatogenesis. It interacts with cyclophilin family and acts as a signaling receptor to extracellular cyclophilins A and B. EMMPRIN expression in epithelial ovarian cancers (EOC) is higher than in benign ovarian tumors and normal ovaries. It is associated with the pathogenesis of acute coronary syndrome (ACS) and may act as a biomarker for ACS. EMMPRIN plays important roles in tumor progression and sunitinib resistance in renal cell carcinoma (RCC). It could act as a novel target for the treatment of RCC.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Shasha Xu et al.
Clinical and investigative medicine. Medecine clinique et experimentale, 36(6), E282-E289 (2013-12-07)
Leukotriene B4 (LTB4) and extracellular matrix metalloproteinase (EMMPRIN) have been suggested as modulators of atherosclerotic plaque instability. This study sought to evaluate the potential diagnostic implication of LTB4 and EMMPRIN in patients with acute coronary syndrome (ACS). Patients (n=153) who
Vyacheslav Yurchenko et al.
Immunology, 117(3), 301-309 (2006-02-16)
CD147 is a widely expressed plasma membrane protein that has been implicated in a variety of physiological and pathological activities. It is best known for its ability to function as extracellular matrix metalloproteinase inducer (hence the other name for this
Mototaka Sato et al.
PloS one, 8(9), e74313-e74313 (2013-09-28)
Extracellular matrix metalloproteinase inducer (EMMPRIN) has been reported to play crucial roles, including in angiogenesis, in several carcinomas. However, the correlation between EMMPRIN levels and angiogenesis expression profile has not been reported, and the role of EMMPRIN in renal cell
Sebastian Szubert et al.
Journal of cancer research and clinical oncology, 140(3), 361-369 (2014-01-01)
The primary aim of this paper was to evaluate the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) and its relationship with proangiogenic factors and microvessel density (MVD) in ovarian cancer. The study group included 58 epithelial ovarian cancers (EOCs), 35
Aihong Jin et al.
Fertility and sterility, 101(6), 1681-1687 (2014-03-26)
To examine the expression of CD147 in 60 human endometriosis lesions and how CD147 regulates migration and apoptosis in human uterine epithelial (HESs) cells. Experimental clinical study and laboratory-based investigation. Hospital and academic research center. Sixty women with chocolate cysts
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