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Key Documents

A5737

Sigma-Aldrich

Cefotetan disodium

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About This Item

Empirical Formula (Hill Notation):
C17H15N7Na2O8S4
CAS Number:
74356-00-6
Molecular Weight:
619.58
UNSPSC Code:
51282206
NACRES:
NA.85

form

powder

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

Mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

InChI

1S/C17H17N7O8S4.2Na/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28;;/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30);;/q;2*+1/p-2/b12-6-;;/t13?,15-,17+;;/m1../s1

InChI key

ZQQALMSFFARWPK-GLHLDKNHSA-L

Biochem/physiol Actions

Cefotetan (cefotan) is a second-generation cephalosporin that is active against some strains of β-lactamase producing bacteria. It shows anti-microbial activity against Gram-positive and Gram-negative bacteria; it is more efficacious against Gram-negative and anaerobic bacteria. Cefotetan binds to penicillin-binding proteins and disrupts the cell wall synthesis.
Cefotetan has good protein binding capacity due to its half-life of 3 to 4 hours. The presence of methylthiotetrazole (MTT) side chain helps to enhance its potential for hypoprothrombinemia and disulfiram reactions. It possesses high antimicrobial activity against gram-negative bacilli than cefoxitin.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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S Y Lee et al.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 13(5), 539-541 (2007-03-03)
This study evaluated the accuracy of cefotetan susceptibility determination using the MicroScan WalkAway system for AmpC-producing Klebsiella pneumoniae. In total, 57 K. pneumoniae isolates that showed a D-shape flattening in a double-disk synergy test were studied. Cefotetan MICs were determined
James E Kendrick et al.
Journal of the American College of Surgeons, 207(3), 393-397 (2008-08-30)
To develop a standardized protocol for management of postoperative fever in gynecology patients to decrease unnecessary diagnostic workups and empiric use of antibiotics. A prospective analysis of postoperative gynecology patients identified those who experienced fever (maximum temperature [T(max)] > 100.4
Najjia N Mahmoud et al.
Surgical infections, 10(6), 539-544 (2009-08-28)
Length of stay (LOS) and inpatient costs for open-abdomen colorectal procedures have not been examined recently. The aim of this study was to determine LOS and costs for several colorectal procedures in the context of factors potentially associated with surgical
Samuel E Wilson et al.
Surgical infections, 9(3), 349-356 (2008-06-24)
The costs of treating surgical site infections can be considerable. There is a cost associated with the prophylactic use of antibiotics; however, the use of prophylactic agents may reduce infection rates and lengths of stay, thus offsetting the overall treatment
Drug-induced immune hemolytic anemia.
George Garratty
Clinical advances in hematology & oncology : H&O, 8(2), 98-101 (2010-04-14)
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