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236M-9

Sigma-Aldrich

CEA (CEA31) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

CEA31, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (236M-94)
vial of 0.5 mL concentrate (236M-95)
bottle of 1.0 mL predilute (236M-97)
vial of 1.0 mL concentrate (236M-96)
bottle of 7.0 mL predilute (236M-98)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG1

control

colon

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... CEACAM5(1048)

General description

Anti-CEA is an antibody against carcinoembryonic antigen (CEA), a protein thought to promote tumor development through its role as a cell adhesion molecule. Anti-CEA positivity is seen in adenocarcinomas of many origins, especially colon and lung adenocarcinomas, but is rarely seen in mesothelial cells and mesotheliomas.

Quality


IVD
IVD
IVD
RUO

Linkage

CEA Positive Control Slides, Product No. 236S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

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V L Go
Cancer, 37(1 suppl), 562-566 (1976-01-01)
Carcinoembryionic antigen (CEA) a glycoprotein extracted from colonic cancer tissue (beta-globulin electrophoretic mobility, sedimentation coefficient 7 to 8S, and mol wt approximately 200,000) can be detected and measured by radioimmunoassay. Clinical evaluations of CEA determination have given the following results:
H Kamino et al.
Cancer, 61(6), 1142-1148 (1988-03-15)
Forty nasopharyngeal carcinomas (NPC) were studied by immunohistochemistry using an antibody to involucrin and the following three keratin antibodies: (1) an antibody to low molecular weight keratin reactive with nonsquamous epithelium, (2) a high molecular weight keratin antibody reactive with
J H Lagendijk et al.
Journal of clinical pathology, 52(4), 283-290 (1999-09-04)
To discriminate between adenocarcinomas that are primary to the ovary and metastatic to the ovary, especially of colonic and breast origin, by immunohistochemistry, using stepwise discriminant analysis or a decision tree. 312 routinely processed, formalin fixed tissue specimens were used.
V Tron et al.
Archives of pathology & laboratory medicine, 111(3), 291-293 (1987-03-01)
Immunohistologic markers have been of considerable value in differentiating malignant mesothelioma from adenocarcinoma. Recently, staining for milk-fat globule (MFG) protein has been suggested as a useful diagnostic test for this separation, but subsequent reports have been conflicting, with some authors
Julu Bhatnagar et al.
Anticancer research, 22(3), 1849-1857 (2002-08-10)
Although the prognostic value of Carcinoembryonic antigen (CEA) in colorectal cancer follow-up is well known, CEA expression in esophageal cancer is not widely recognized and studies correlating tissue CEA expression in stomach cancers with tumor differentiation have yielded contradictory results.
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