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Y0000821

Molsidomine

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

N-(Ethoxycarbonyl)-3-(4-morpholino)sydnone imine, SIN-10

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About This Item

Empirical Formula (Hill Notation):
C9H14N4O4
CAS Number:
25717-80-0
Molecular Weight:
242.23
MDL number:
MFCD00869301
UNSPSC Code:
41116107
PubChem Substance ID:
329831170
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

molsidomine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CCOC(=O)N=C1O[N-][N+](=C1)N2CCOCC2

InChI

1S/C9H14N4O4/c1-2-16-9(14)10-8-7-13(11-17-8)12-3-5-15-6-4-12/h7H,2-6H2,1H3/b10-8-

InChI key

XLFWDASMENKTKL-NTMALXAHSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Molsidomine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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R E Nitz et al.
Pharmacotherapy, 7(1), 28-37 (1987-01-01)
The long-acting antianginal drug molsidomine has been shown experimentally to reduce myocardial infarct size when administered prior to or after cardiac insult. This is due to several drug actions. Dilation of postcapillary capacitance vessels diminishes venous return, preload, heart dimensions
[Molsidomine (Corvaton)].
O M Eliseev
Terapevticheskii arkhiv, 66(9), 82-88 (1994-01-01)
R E Nitz et al.
American heart journal, 109(3 Pt 2), 631-636 (1985-03-01)
The cardioprotective and antithrombotic activity of molsidomine, a novel therapeutic agent for the treatment of coronary heart disease, was investigated in a series of animal models of myocardial ischemia. Molsidomine given to dogs with marked ST segment elevation (epicardial electrogram)
[Pharmacology of molsidomine and its active metabolites].
E Böhme
Medizinische Klinik (Munich, Germany : 1983), 85 Suppl 1, 7-10 (1990-02-01)
[Treatment of myocardial ischemia with molsidomine].
J Dirschinger et al.
Medizinische Klinik (Munich, Germany : 1983), 85(3), 141-144 (1990-03-15)
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