W245735

Ethyl pyruvate

≥97%, FG

• Synonym(s): Ethyl 2-oxopropanoate, Ethyl 2-oxopropionate, Ethyl acetyl formate, Ethyl pyroracemate, Pyruvic acid ethyl ester
• Linear Formula: CH₃COCOOC₂H₅
• CAS Number: 617-35-6
• Molecular Weight: 116.12
• FEMA Number: 2457
• Beilstein: 1071466
• EC Number: 210-511-2
• Council of Europe no.: 430
• MDL number: MFCD00009123
• UNSPSC Code: 12164502
• PubChem Substance ID: 329830492
• Flavis number: 9.442
• NACRES: NA.21

Properties

• biological source: synthetic
• Quality Level: 400
• grade: FG; Halal; Kosher
• Agency: meets purity specifications of JECFA
• reg. compliance: EU Regulation 1334/2008 & 178/2002; FDA 21 CFR 117; FDA 21 CFR 172.515
• Assay: ≥97%
• refractive index: n20/D 1.404 (lit.)
• bp: 144 °C (lit.)
• density: 1.045 g/mL at 25 °C (lit.)
• application(s): flavors and fragrances
• Documentation: see Safety & Documentation for available documents
• food allergen: no known allergens
• Organoleptic: fruity; ethereal; rum; sweet
• SMILES string: CCOC(=O)C(C)=O
• InChI: 1S/C5H8O3/c1-3-8-5(7)4(2)6/h3H2,1-2H3
• InChI key: XXRCUYVCPSWGCC-UHFFFAOYSA-N

Description

Application

• High mobility group box 1 in the central nervous system: regeneration hidden beneath inflammation.: This study explores the role of high mobility group box 1 (HMGB1) in the central nervous system, focusing on its regenerative capabilities despite its inflammatory properties. Ethyl pyruvate was identified as a potential therapeutic agent in mitigating inflammation and promoting neural regeneration (Kim et al., 2025).


• Immunomodulation of Ethyl pyruvate on gestational diabetes mellitus in Mice; The impact on Th17/Treg balance.: This study investigates the effects of ethyl pyruvate on gestational diabetes mellitus (GDM) in mice, focusing on its immunomodulatory effects and its impact on the Th17/Treg balance, highlighting its potential benefits in managing GDM (Zhao et al., 2024).


• HMGB1/RAGE axis in tumor development: unraveling its significance.: The review delves into the HMGB1/RAGE axis in tumor development, examining its significance and the potential therapeutic role of ethyl pyruvate in targeting this pathway to inhibit tumor growth and progression (Fan et al., 2024).


• Ethyl pyruvate ameliorates acute respiratory distress syndrome in mice.: This article highlights the therapeutic potential of ethyl pyruvate in ameliorating acute respiratory distress syndrome (ARDS) in a mouse model, showcasing its anti-inflammatory and protective effects (Micanovic et al., 2024).

Safety Information

• Pictograms: GHS02,GHS05
• Signal Word: Danger
• Hazard Statements: H226,H314,H412
• Precautionary Statements: P210 - P233 - P273 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Aquatic Chronic 3 - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 114.8 °F - closed cup
• Flash Point(C): 46 °C - closed cup