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A8309

Sigma-Aldrich

Acethydrazide

90%

Synonym(s):

Acetic acid hydrazide, Acetylhydrazine

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About This Item

Linear Formula:
CH3CONHNH2
CAS Number:
1068-57-1
Molecular Weight:
74.08
Beilstein:
506165
EC Number:
213-948-7
MDL number:
MFCD00007610
UNSPSC Code:
12352100
PubChem Substance ID:
24891331
NACRES:
NA.22

Assay

90%

form

flakes

impurities

<10% acetic acid

bp

129 °C/18 mmHg (lit.)

mp

58-68 °C (lit.)

SMILES string

CC(=O)NN

InChI

1S/C2H6N2O/c1-2(5)4-3/h3H2,1H3,(H,4,5)

InChI key

OFLXLNCGODUUOT-UHFFFAOYSA-N

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General description

Acethydrazide is an organic building that undergo catalytic hydrogenation to produce N′-methyl acethydrazide (MAH).

Application

Acethydrazide can be used in the synthesis of (E)-N′-(2-hydroxybenzylidene)acetohydrazide, an ONO pincer ligand.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H301,H315,H319,H341,H351

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2 - Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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N E Preece et al.
Journal of chromatography, 573(2), 227-234 (1992-01-17)
Plasma and liver levels of hydrazine were determined at 10, 30, 90 and 270 min in rats given 0.09, 0.27, 0.84 and 2.53 mmol of hydrazine per kg body weight orally by capillary gas chromatography-mass spectrometry of its pentafluorobenzaldehyde adduct
Shahrzad Tafazoli et al.
Toxicology and applied pharmacology, 229(1), 94-101 (2008-02-26)
Isoniazid is an anti-tuberculosis drug that can cause hepatotoxicity in 20% of patients that is usually associated with an inflammatory response. Hepatocytes when exposed to non-toxic levels of H2O2, to simulate H2O2 formation by inflammatory cells, became twice as sensitive
D J Fort et al.
Teratogenesis, carcinogenesis, and mutagenesis, 10(6), 463-476 (1990-01-01)
The developmental toxicity of isoniazid (INH) and the metabolites acetylhydrazide (AH) and isonicotinic acid (INA) were examined with the frog embryo teratogenesis assay-Xenopus (FETAX). Late Xenopus laevis blastulae were exposed to INH, AH, and INA for 96 h in two
Victoria E Richards et al.
Toxicological sciences : an official journal of the Society of Toxicology, 82(1), 318-332 (2004-07-30)
Hydrazine (HD) and acetylhydrazine (AcHD) are metabolites of the antituberculosis drug isoniazid (INH) that have been implicated in INH-induced liver damage. The hepatotoxicity of AcHD and HD were compared in adult male C57Bl/6J mice by evaluating hepatic histopathology, plasma biochemistry
B K Sinha
Biochimica et biophysica acta, 924(2), 261-269 (1987-05-19)
Spin-trapping techniques and electron spin resonance spectroscopy have been used to study bioactivations of hydrazine and its derivatives by isolated perfused rat livers. Using phenylbutylnitrone (PBN) as the stable spin trap, it was found that the liver perfusion of hydrazine
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