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Sigma-Aldrich

Bis(hexamethylene)triamine

high purity

Synonym(s):

6,6′-Iminodihexylamine, Bis(6-aminohexyl)amine

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About This Item

Linear Formula:
NH2(CH2)6NH(CH2)6NH2
CAS Number:
143-23-7
Molecular Weight:
215.38
Beilstein:
2323517
EC Number:
205-593-1
MDL number:
MFCD00010448
UNSPSC Code:
12352100
PubChem Substance ID:
24866405
NACRES:
NA.22

vapor pressure

<0.01 mmHg ( 25 °C)

form

solid

refractive index

n20/D 1.49 (lit.)

bp

163-165 °C/4 mmHg (lit.)

mp

33-36 °C (lit.)

density

0.85 g/mL at 20 °C (lit.)
0.879 g/mL at 25 °C

SMILES string

NCCCCCCNCCCCCCN

InChI

1S/C12H29N3/c13-9-5-1-3-7-11-15-12-8-4-2-6-10-14/h15H,1-14H2

InChI key

MRNZSTMRDWRNNR-UHFFFAOYSA-N

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General description

Bis(hexamethylene)triamine (Bis-HEA, BHMT, BHMTA) is an aliphatic polyamine. It is a spermidine analog and has been reported to lack the enhancing effect on mitochondrial Ca(2+) accumulation but shows inhibitory effect on the Ca(2+) and Pi-induced mitochondrial permeability transition. Its ability in inhibiting shale swelling and dispersion in water-based drilling fluid has been investigated.

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 1

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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I Rustenbeck et al.
Biochemistry and molecular biology international, 38(5), 1003-1011 (1996-04-01)
The aliphatic polyamine bis(hexamethylene)triamine, a spermidine analogue, was found to lack the enhancing effect on mitochondrial Ca(2+) accumulation which is typical for the natural polyamines, spermidine and spermine. However, like spermine and spermidine, this compound had a significant inhibitory effect
P A Marks et al.
Proceedings of the National Academy of Sciences of the United States of America, 86(16), 6358-6362 (1989-08-01)
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