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193941

Sigma-Aldrich

4-Chlorophenoxyacetyl chloride

98%

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About This Item

Linear Formula:
ClC6H4OCH2COCl
CAS Number:
4122-68-3
Molecular Weight:
205.04
EC Number:
223-923-2
MDL number:
MFCD00000727
UNSPSC Code:
12352100
PubChem Substance ID:
24851623
NACRES:
NA.22

Assay

98%

refractive index

n20/D 1.5486 (lit.)

bp

142 °C/17 mmHg (lit.)

mp

18.8 °C (lit.)

density

1.314 g/mL at 25 °C (lit.)

SMILES string

ClC(=O)COc1ccc(Cl)cc1

InChI

1S/C8H6Cl2O2/c9-6-1-3-7(4-2-6)12-5-8(10)11/h1-4H,5H2

InChI key

VRBVHQUSAOKVDH-UHFFFAOYSA-N

Application

4-Chlorophenoxyacetyl chloride was used in the preparation of:
  • substituted acetophenone derivatives
  • 2-(4-chlorophenoxyacetylamino)-3-ethoxycarbonyl[2,3-b]quinuclidine
  • 2-(4-chlorophenoxy)-N′-[2-(4-chlorophenoxy)acetyl]acetohydrazide monohydrate

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCJ6241
MKCF6659
MKBZ2040V
MKBQ0362V
03514HH

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Ting Chen et al.
Acta crystallographica. Section E, Structure reports online, 66(Pt 11), o2829-o2829 (2010-01-01)
In the title compound, C(16)H(14)Cl(2)N(2)O(4)·H(2)O, the hydrazine and water mol-ecules are both located on twofold axes. The C-N-N-C torsion angle is -72.66 (1)° and the dihedral angle between the two benzene rings is 67.33 (1)°. In the crystal, mol-ecules are linked into
Synthesis and properties of 2-amino-3-ethycarbonylthieno [2, 3-b] quinuclidines.
Kaminka ME, et al.
Pharmaceutical Chemistry Journal, 21(8), 568-570 (1987)
Jonathan Rosen et al.
Organic letters, 9(4), 667-669 (2007-01-27)
A direct and efficient method was developed for the preparation of a variety of substituted acetophenone derivatives from readily available arene precursors and acid chlorides. This method has significant generality and affords access to substitution patterns on aryl rings not

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