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Supelco

Astec® CHIROBIOTIC® R Chiral (5 μm) HPLC Columns

L × I.D. 15 cm × 2.1 mm, HPLC Column

Synonym(s):

CHIROBIOTIC R Chiral Chromatography Column

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About This Item

UNSPSC Code:
41115700
eCl@ss:
32110501
NACRES:
SB.52

product name

Astec® CHIROBIOTIC® R Chiral HPLC Column, 5 μm particle size, L × I.D. 15 cm × 2.1 mm

material

stainless steel column

Quality Level

100

description

HPLC column

product line

Astec®

packaging

pkg of 1 ea

manufacturer/tradename

Astec®

parameter

0-45 °C temperature
241 bar pressure (3500 psi)

technique(s)

HPLC: suitable
LC/MS: suitable

L × I.D.

15 cm × 2.1 mm

matrix

high-purity silica gel particle platform
fully porous particle

matrix active group

ristocetin A glycopeptide phase

particle size

5 μm

pore size

100 Å

operating pH range

3.5-6.8

separation technique

chiral

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General description

CHIROBIOTIC® R, based on the ristocetin A glycopeptide covalently bonded to high purity silica particles, has shown particular applicability to enantiomers of anionic compounds. Selectivity on CHIROBIOTIC® R strongly correlates to the organic modifier, favoring the alcohol-type mobile phases by a large margin.

  • Bonded phase: Ristocetin A
  • Operating pH range: 3.5 - 6.8
  • Particle diameter: 5, 10 or 16 μm
  • Pore size: 100 Å

CHIROBIOTIC FAQs
CHIROBIOTIC Reference Bibliography
Chiral Product Literature

Application


  • Sensitive determination of D-lactic acid and L-lactic acid in urine by high-performance liquid chromatography-tandem mass spectrometry.: This study demonstrates the application of the Astec CHIROBIOTIC R Chiral HPLC Column in the sensitive determination of D-lactic acid and L-lactic acid in urine samples using HPLC-MS/MS. This highlights its utility in clinical and biomedical research for the analysis of chiral molecules in biological fluids (Henry et al., 2012).

  • New high-performance liquid chromatography method for the determination of (R)-warfarin and (S)-warfarin using chiral separation on a glycopeptide-based stationary phase.: This research utilizes the Astec CHIROBIOTIC R Chiral HPLC Column to develop a method for the chiral separation and determination of warfarin enantiomers. It underscores the column′s application in pharmaceutical analysis, particularly in the study of chiral drug enantiomers (Malakova et al., 2009).



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Legal Information

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC

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Certificates of Analysis (COA)

Lot/Batch Number
292262-01
292211-01
292210-01
292037-01
287397-01

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Enzyme-catalyzed synthesis of (R)- and (S)-3-hydroxy-3-(10-alkyl-10H-phenothiazin-3-yl)propanoic acids
Brem, Jurgen, et al.
Tetrahedron Asymmetry, 21 (3), 365-373 (2010)
H Henry et al.
Biomedical chromatography : BMC, 26(4), 425-428 (2011-08-16)
D-lactic acid in urine originates mainly from bacterial production in the intestinal tract. Increased D-lactate excretion as observed in patients affected by short bowel syndrome or necrotizing enterocolitis reflects D-lactic overproduction. Therefore, there is a need for a reliable and
P Dehouck et al.
Journal of chromatography. A, 1010(1), 63-74 (2003-09-25)
Erythromycin is a mixture of macrolide antibiotics produced by Saccharopolyspora erythreas during fermentation. A new method for the analysis of erythromycin by liquid chromatography has previously been developed. It makes use of an Astec C18 polymeric column. After validation in
Enzyme-catalyzed synthesis of (R)- and (S)-3-heteroaryl-3-hydroxy-propanoic acids and their derivatives
Brem, Jurgen, et al.
Tetrahedron Asymmetry, 20 (4), 489-496 (2009)
G Bellucci et al.
Chirality, 6(3), 207-212 (1994-01-01)
The rabbit liver microsomal biotransformation of alpha-methylstyrene (1a), 2-methyl-1-hexene (1b), 2,4,4-trimethyl-1-pentene (1c), and 1,3,3-trimethyl-1-butene (1d) has been investigated with the aim at establishing the enantioface selection of the cytochrome P-450-promoted epoxidation of the double bond and the enantioselectivity of microsomal
View All Related Papers

Protocols

Determination of L- and D-Lactic Acid Enantiomers by HPLC/MS/MS

Rapid, simple, reproducible chiral separation and quantification of L- and D-lactic acid enantiomers using Supelco’s Astec CHIROBIOTIC® R chiral column and tandem MS.

Determination of L- and D-Lactic Acid Enantiomers by HPLC/MS/MS

Rapid, simple, reproducible chiral separation and quantification of L- and D-lactic acid enantiomers using Supelco’s Astec CHIROBIOTIC® R chiral column and tandem MS.

Determination of L- and D-Lactic Acid Enantiomers by HPLC/MS/MS

Rapid, simple, reproducible chiral separation and quantification of L- and D-lactic acid enantiomers using Supelco’s Astec CHIROBIOTIC® R chiral column and tandem MS.

Determination of L- and D-Lactic Acid Enantiomers by HPLC/MS/MS

Rapid, simple, reproducible chiral separation and quantification of L- and D-lactic acid enantiomers using Supelco’s Astec CHIROBIOTIC® R chiral column and tandem MS.

Chromatograms

application for HPLCapplication for HPLC

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