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SAB4503912

Sigma-Aldrich

Anti-phospho-ETS1 (pThr38) antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 50 kDa

species reactivity

rat, human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pThr38)

Gene Information

human ... ETS1(2113)

General description

ETS1 (E26 transformation specific sequence 1) is a proto‐oncogene. It is a member of the family of ETS transcriptional factors. ETS1 is usually expressed in lymphoid cells. This gene is mapped to human chromosome 11q24.

Immunogen

The antiserum was produced against synthesized peptide derived from human ETS1 around the phosphorylation site of Thr38.

Immunogen Range: 11-60

Biochem/physiol Actions

ETS1 (E26 transformation specific sequence 1) participates in Pol ι‐mediated progression of ESCC (esophageal squamous cell carcinoma). This gene controls cancer cell invasion, metastasis and EMT (epithelial to mesenchymal transition). ETS1 also plays important roles in the lymphocyte development, function, apoptosis and inflammation.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Phosphorylation of ETS-1 is a critical event in DNA polymerase iota-induced invasion and metastasis of esophageal squamous cell carcinoma
He C, et al.
Cancer Science, 108(12), 2503-2510 (2017)
Association of E26 Transformation Specific Sequence 1 Variants with Rheumatoid Arthritis in Chinese Han Population
Chen L, et al.
PLoS ONE, 10(8) (2015)
Submicroscopic deletions of 11q24-25 in individuals without Jacobsen syndrome: re-examination of the critical region by high-resolution array-CGH
Tyson C, et al.
Molecular Cytogenetics (2008)
Yingxue Hao et al.
MedComm, 4(1), e202-e202 (2023-01-14)
The regenerative capacity of skeletal muscle is dependent on satellite cells. The circadian clock regulates the maintenance and function of satellite cells. Cryptochrome 2 (CRY2) is a critical component of the circadian clock, and its role in skeletal muscle regeneration

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